Assay Detail
Binding
CHEMBL3631405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP-10 (unknown origin) mediated ADP-ribosylation of SRPK2 by fluorescence analysis using 3 uM SRPK2 as a substrate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP10 (CHEMBL2429708) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective inhibition of PARP10 using a chemical genetics strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.09 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688212 | — | — | 1 | 4.52 |
| CHEMBL3629672 | — | — | 1 | 4.00 |
| CHEMBL3416132 | — | — | 1 | 4.00 |
| CHEMBL3629673 | — | — | 1 | 4.00 |
| CHEMBL3629674 | — | — | 1 | 4.00 |
| CHEMBL3629675 | — | — | 1 | 4.00 |
| CHEMBL3629676 | — | — | 1 | - |
| CHEMBL3629677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688212 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3629672 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3416132 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3629673 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3629674 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3629675 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3629676 | — | IC50 | - | — | - | |
| CHEMBL3629677 | — | IC50 | > | 100000.0 | nM | - |