Assay Detail
Binding
CHEMBL3632095
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Inhibition of TAK1 (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 7 (CHEMBL5776) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.23 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077979 | — | — | 1 | 7.96 |
| CHEMBL471474 | HYPOTHEMYCIN | — | 1 | 7.48 |
| CHEMBL3629241 | — | — | 1 | 7.11 |
| CHEMBL3629242 | — | — | 1 | 6.44 |
| CHEMBL3629243 | — | — | 1 | 6.42 |
| CHEMBL3629244 | — | — | 1 | 6.00 |
| CHEMBL1801950 | — | — | 1 | 5.89 |
| CHEMBL1801951 | — | — | 1 | 5.58 |
| CHEMBL3629245 | — | — | 1 | 5.58 |
| CHEMBL3629246 | — | — | 1 | 5.05 |
| CHEMBL1099228 | ZEAENOL | — | 1 | 5.00 |
| CHEMBL3628303 | — | — | 1 | - |
| CHEMBL3629248 | — | — | 1 | - |
| CHEMBL3334712 | — | — | 1 | - |
| CHEMBL3629247 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077979 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL471474 | HYPOTHEMYCIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3629241 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3629242 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3629243 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3629244 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL1801950 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1801951 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3629245 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3629246 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1099228 | ZEAENOL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3628303 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3629248 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3334712 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3629247 | — | IC50 | > | 30000.0 | nM | - |