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Assay Detail

CHEMBL3635184

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Physicochemical
Antioxidant activity assessed as inhibition of Fe2+-induced DMPO-OH adduct formation from H2O2 preincubated for 30 secs followed by DMPO/H2O2 addition measured after 150 secs by ESR analysis
13
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Physicochemical
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action.
Azran S, Danino O, Förster D, Kenigsberg S, Reiser G, Dixit M, Singh V, Major DT, Fischer B.
J Med Chem (2015) 58 : 8427 -8443
PubMed 26447940 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.50 4.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL335206 1 4.72
CHEMBL3634186 1 4.68
CHEMBL3634185 1 4.68
CHEMBL3634184 2 4.57
CHEMBL575257 2 4.51
CHEMBL3634183 2 4.44
CHEMBL3634182 2 4.43
CHEMBL858 EDETIC ACID 3.0 1 4.27
CHEMBL14830 ADENOSINE DIPHOSPHATE 0.5 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL335206 IC50 = 19000.0 nM 4.72
CHEMBL3634186 IC50 = 21000.0 nM 4.68
CHEMBL3634185 IC50 = 21000.0 nM 4.68
CHEMBL3634184 IC50 = 27000.0 nM 4.57
CHEMBL575257 IC50 = 31000.0 nM 4.51
CHEMBL3634183 IC50 = 36000.0 nM 4.44
CHEMBL575257 IC50 = 36000.0 nM 4.44
CHEMBL3634184 IC50 = 37000.0 nM 4.43
CHEMBL3634182 IC50 = 37000.0 nM 4.43
CHEMBL3634182 IC50 = 38000.0 nM 4.42
CHEMBL3634183 IC50 = 39000.0 nM 4.41
CHEMBL858 EDETIC ACID IC50 = 54000.0 nM 4.27
CHEMBL14830 ADENOSINE DIPHOSPHATE IC50 = 170000.0 nM -