Assay Detail
Binding
CHEMBL3635223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of full length human PXR transfected in human HepG2 cells after 18 hrs by luciferase reporter assay relative to rifaximin
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 1 group I member 2 (CHEMBL3401) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diethylstilbestrol-scaffold-based pregnane X receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.97 | 4.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113650 | — | — | 1 | 4.98 |
| CHEMBL1617 | RIFAXIMIN | 4.0 | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113650 | — | EC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1617 | RIFAXIMIN | EC50 | = | 11200.0 | nM | 4.95 |