Assay Detail
Binding
CHEMBL3635403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of xenopus porcupine expressed in human HT1080 cells assessed as reduction in beta catenin reporter activity using firefly luciferase substrate STF reporter assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Xenopus |
| Cell Type | HT-1080 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The use of porcupine inhibitors to target Wnt-driven cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.16 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3633802 | ETC-159 | 1.0 | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3633802 | ETC-159 | IC50 | = | 70.0 | nM | 7.16 |