Assay Detail
Toxicity
CHEMBL3635778
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Hepatotoxicity in human HepG2 cells assessed as cell viability after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.33 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3632992 | — | — | 1 | 6.16 |
| CHEMBL3632851 | — | — | 1 | 6.04 |
| CHEMBL3410954 | — | — | 1 | 5.70 |
| CHEMBL3632846 | — | — | 1 | 5.31 |
| CHEMBL292314 | — | — | 1 | 5.15 |
| CHEMBL3410953 | — | — | 1 | 5.06 |
| CHEMBL1256415 | — | — | 1 | 4.94 |
| CHEMBL3632987 | — | — | 1 | 4.88 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3632992 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3632851 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3410954 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3632846 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL292314 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL3410953 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL1256415 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL3632987 | — | IC50 | = | 13190.0 | nM | 4.88 |
| CHEMBL95 | TACRINE | IC50 | = | 19370.0 | nM | 4.71 |