Assay Detail
Functional
CHEMBL3635930
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Cytotoxicity against human A549 cells assessed as decrease in cell viability at 10 to 100 uM after 48 hrs by SRB assay
9
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 5 | - | - |
| EC50 | 4 | 4.60 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.28 |
| CHEMBL3633245 | — | — | 2 | 4.48 |
| CHEMBL3632630 | — | — | 2 | 4.34 |
| CHEMBL3633244 | — | — | 2 | 4.31 |
| CHEMBL3633246 | — | — | 1 | - |
| CHEMBL3633247 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3633245 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3632630 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3633244 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL3633246 | — | Activity | - | — | - | |
| CHEMBL3633247 | — | Activity | - | — | - | |
| CHEMBL3632630 | — | Activity | - | — | - | |
| CHEMBL3633244 | — | Activity | - | — | - | |
| CHEMBL3633245 | — | Activity | - | — | - |