Assay Detail
Binding
CHEMBL3636058
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Inhibition of VEGFR-2 (unknown origin) after 1 hr by ADP-Glo assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel VEGFR-2 inhibitors. Part 5: Exploration of diverse hinge-binding fragments via core-refining approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.02 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.32 |
| CHEMBL3633294 | — | — | 1 | 9.30 |
| CHEMBL3633304 | — | — | 1 | 9.10 |
| CHEMBL3633684 | — | — | 1 | 8.86 |
| CHEMBL3633292 | — | — | 1 | 8.67 |
| CHEMBL3633296 | — | — | 1 | 8.64 |
| CHEMBL3633295 | — | — | 1 | 8.63 |
| CHEMBL3633686 | — | — | 1 | 8.46 |
| CHEMBL3633298 | — | — | 1 | 7.68 |
| CHEMBL3633271 | — | — | 1 | 7.55 |
| CHEMBL3633303 | — | — | 1 | 7.38 |
| CHEMBL3633290 | — | — | 1 | 7.27 |
| CHEMBL3633291 | — | — | 1 | 7.23 |
| CHEMBL3633273 | — | — | 1 | 7.21 |
| CHEMBL3633293 | — | — | 1 | 6.94 |
| CHEMBL3633302 | — | — | 1 | 6.93 |
| CHEMBL3633277 | — | — | 1 | 6.80 |
| CHEMBL3633301 | — | — | 1 | 6.69 |
| CHEMBL3633297 | — | — | 1 | 6.48 |
| CHEMBL3633288 | — | — | 1 | 5.33 |
| CHEMBL3633275 | — | — | 1 | 5.27 |
| CHEMBL3633280 | — | — | 1 | 5.08 |
| CHEMBL3633289 | — | — | 1 | 4.83 |
| CHEMBL3633278 | — | — | 1 | 4.42 |
| CHEMBL3633276 | — | — | 1 | 4.29 |
| CHEMBL3633274 | — | — | 1 | 4.28 |
| CHEMBL3633281 | — | — | 1 | - |
| CHEMBL3633685 | — | — | 1 | - |
| CHEMBL3633305 | — | — | 1 | - |
| CHEMBL3633272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL3633294 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3633304 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL3633684 | — | IC50 | = | 1.38 | nM | 8.86 |
| CHEMBL3633292 | — | IC50 | = | 2.15 | nM | 8.67 |
| CHEMBL3633296 | — | IC50 | = | 2.28 | nM | 8.64 |
| CHEMBL3633295 | — | IC50 | = | 2.36 | nM | 8.63 |
| CHEMBL3633686 | — | IC50 | = | 3.47 | nM | 8.46 |
| CHEMBL3633298 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3633271 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3633303 | — | IC50 | = | 41.8 | nM | 7.38 |
| CHEMBL3633290 | — | IC50 | = | 53.6 | nM | 7.27 |
| CHEMBL3633291 | — | IC50 | = | 59.2 | nM | 7.23 |
| CHEMBL3633273 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3633293 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL3633302 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3633277 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3633301 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL3633297 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL3633288 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3633275 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3633280 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3633289 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL3633278 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL3633276 | — | IC50 | = | 51900.0 | nM | 4.29 |
| CHEMBL3633274 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL3633299 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3633300 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3633287 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3633286 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3633285 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3633284 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3633283 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3633282 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3633279 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3633272 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3633305 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3633685 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL3633281 | — | IC50 | > | 500000.0 | nM | - |