Assay Detail
Binding
CHEMBL3636166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged human recombinant VEGFR2 kinase expressed in Sf9 insect cells by radiometric protein kinase assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Ynamide Click chemistry in development of triazole VEGFR2 TK modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.40 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194176 | — | — | 1 | 7.66 |
| CHEMBL3633692 | — | — | 1 | 5.16 |
| CHEMBL3633690 | — | — | 1 | 4.40 |
| CHEMBL3633696 | — | — | 1 | 4.38 |
| CHEMBL3633695 | — | — | 1 | - |
| CHEMBL3633694 | — | — | 1 | - |
| CHEMBL3633693 | — | — | 1 | - |
| CHEMBL3633691 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194176 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3633692 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL3633690 | — | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL3633696 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL3633695 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3633694 | — | IC50 | - | — | - | |
| CHEMBL3633693 | — | IC50 | - | — | - | |
| CHEMBL3633691 | — | IC50 | > | 100000.0 | nM | - |