Assay Detail
Binding
CHEMBL3636229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DTG from sigma2 receptor in rat liver membranes incubated for 120 mins by scintillation counting method in presence of pentazocine
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.04 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.19 |
| CHEMBL3633572 | — | — | 1 | 6.96 |
| CHEMBL3633571 | — | — | 1 | 6.76 |
| CHEMBL3633401 | — | — | 1 | 6.16 |
| CHEMBL3633404 | — | — | 1 | 6.08 |
| CHEMBL3633403 | — | — | 1 | 6.00 |
| CHEMBL3633399 | — | — | 1 | 5.80 |
| CHEMBL3633211 | — | — | 1 | 5.60 |
| CHEMBL3633394 | — | — | 1 | 5.37 |
| CHEMBL3633397 | — | — | 1 | 5.31 |
| CHEMBL3633387 | — | — | 1 | 5.24 |
| CHEMBL3633391 | — | — | 1 | - |
| CHEMBL3633392 | — | — | 1 | - |
| CHEMBL3633393 | — | — | 1 | - |
| CHEMBL3633206 | — | — | 1 | - |
| CHEMBL3633395 | — | — | 1 | - |
| CHEMBL3633396 | — | — | 1 | - |
| CHEMBL3633398 | — | — | 1 | - |
| CHEMBL3633390 | — | — | 1 | - |
| CHEMBL3633400 | — | — | 1 | - |
| CHEMBL3633388 | — | — | 1 | - |
| CHEMBL3633402 | — | — | 1 | - |
| CHEMBL3633210 | — | — | 1 | - |
| CHEMBL3633209 | — | — | 1 | - |
| CHEMBL3633208 | — | — | 1 | - |
| CHEMBL3633207 | — | — | 1 | - |
| CHEMBL3633389 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL3633572 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL3633571 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL3633401 | — | Ki | = | 698.0 | nM | 6.16 |
| CHEMBL3633404 | — | Ki | = | 841.0 | nM | 6.08 |
| CHEMBL3633403 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL3633399 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3633211 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL3633394 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL3633397 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL3633387 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL3633391 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633392 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633393 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633206 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633395 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633396 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633398 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633390 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633400 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633388 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633402 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633210 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633209 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633208 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633207 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633389 | — | Ki | > | 10000.0 | nM | - |