Assay Detail
Binding
CHEMBL3636230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]MK801 from NMDA receptor PCP binding site in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 6.84 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1165411 | DEXOXADROL | 2.0 | 1 | 7.72 |
| CHEMBL305904 | ETOXADROL | 2.0 | 1 | 7.66 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 7.55 |
| CHEMBL3633211 | — | — | 1 | 6.38 |
| CHEMBL395091 | ESKETAMINE | 4.0 | 1 | 6.38 |
| CHEMBL3633387 | — | — | 1 | 6.15 |
| CHEMBL3633210 | — | — | 1 | 6.05 |
| CHEMBL3633395 | — | — | 1 | - |
| CHEMBL3633207 | — | — | 1 | - |
| CHEMBL3633394 | — | — | 1 | - |
| CHEMBL3633393 | — | — | 1 | - |
| CHEMBL3633392 | — | — | 1 | - |
| CHEMBL3633391 | — | — | 1 | - |
| CHEMBL3633390 | — | — | 1 | - |
| CHEMBL3633389 | — | — | 1 | - |
| CHEMBL3633388 | — | — | 1 | - |
| CHEMBL3633209 | — | — | 1 | - |
| CHEMBL3633208 | — | — | 1 | - |
| CHEMBL3633206 | — | — | 1 | - |
| CHEMBL3633571 | — | — | 1 | - |
| CHEMBL3633404 | — | — | 1 | - |
| CHEMBL3633403 | — | — | 1 | - |
| CHEMBL3633402 | — | — | 1 | - |
| CHEMBL3633572 | — | — | 1 | - |
| CHEMBL3633400 | — | — | 1 | - |
| CHEMBL3633399 | — | — | 1 | - |
| CHEMBL3633398 | — | — | 1 | - |
| CHEMBL3633397 | — | — | 1 | - |
| CHEMBL3633396 | — | — | 1 | - |
| CHEMBL3633401 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1165411 | DEXOXADROL | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL305904 | ETOXADROL | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL275528 | PHENCYCLIDINE | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL3633211 | — | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL395091 | ESKETAMINE | Ki | = | 419.0 | nM | 6.38 |
| CHEMBL3633387 | — | Ki | = | 712.0 | nM | 6.15 |
| CHEMBL3633210 | — | Ki | = | 893.0 | nM | 6.05 |
| CHEMBL3633395 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633207 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633394 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633393 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633392 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633391 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633390 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633389 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633388 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633209 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633208 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633206 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633571 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633404 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633403 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633402 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633572 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633400 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633399 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633398 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633397 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633396 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3633401 | — | Ki | > | 10000.0 | nM | - |