Assay Detail
Binding
CHEMBL3636870
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse NaV1.1 by IonWorks quattro automated electrophysiology assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 1 subunit alpha (CHEMBL4523103) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.44 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3632695 | — | — | 1 | 6.17 |
| CHEMBL3634332 | — | — | 1 | 6.16 |
| CHEMBL3632698 | — | — | 1 | 5.62 |
| CHEMBL3634329 | — | — | 1 | 5.51 |
| CHEMBL1200606 | MEXILETINE HYDROCHLORIDE | 4.0 | 1 | 4.68 |
| CHEMBL3634334 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3632695 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3634332 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3632698 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3634329 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1200606 | MEXILETINE HYDROCHLORIDE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3634334 | — | IC50 | = | 34000.0 | nM | 4.47 |