Assay Detail
Functional
CHEMBL3636900
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Antiproliferative activity against human SK-MEL-28 cells harboring B-RAF V600E mutant
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-28 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.46 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3632721 | — | — | 1 | 7.30 |
| CHEMBL3632719 | — | — | 1 | 6.92 |
| CHEMBL558752 | RAF-265 | 2.0 | 1 | 6.80 |
| CHEMBL3335371 | — | — | 1 | 6.75 |
| CHEMBL3632720 | — | — | 1 | 6.64 |
| CHEMBL3632723 | — | — | 1 | 6.22 |
| CHEMBL3632724 | — | — | 1 | 6.13 |
| CHEMBL470808 | — | — | 1 | 6.05 |
| CHEMBL3632718 | — | — | 1 | 5.96 |
| CHEMBL3632722 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3632721 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3632719 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL558752 | RAF-265 | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3335371 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3632720 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3632723 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3632724 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL470808 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3632718 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3632722 | — | IC50 | = | 1620.0 | nM | 5.79 |