Assay Detail
Binding
CHEMBL3636905
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Inhibition of LCK (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.03 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3335371 | — | — | 1 | 8.52 |
| CHEMBL470808 | — | — | 1 | 7.19 |
| CHEMBL3632717 | — | — | 1 | 6.70 |
| CHEMBL3632719 | — | — | 1 | 5.70 |
| CHEMBL558752 | RAF-265 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3335371 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL470808 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3632717 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3632719 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL558752 | RAF-265 | IC50 | > | 6000.0 | nM | - |