Assay Detail
Binding
CHEMBL3637037
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Inhibition of Keap1-NRF2 interaction (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in FITC-9mer NRF2 peptide binding after 1 hr by fluorescence anisotropy assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BL21-DE3 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.49 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237245 | — | — | 1 | 7.62 |
| CHEMBL3617852 | — | — | 1 | 7.21 |
| CHEMBL3632711 | — | — | 1 | 7.20 |
| CHEMBL3632882 | — | — | 1 | 7.07 |
| CHEMBL3632705 | — | — | 1 | 6.72 |
| CHEMBL3632881 | — | — | 1 | 6.39 |
| CHEMBL3632699 | — | — | 1 | 6.20 |
| CHEMBL3632706 | — | — | 1 | 6.18 |
| CHEMBL3632704 | — | — | 1 | 6.05 |
| CHEMBL2402207 | — | — | 1 | 6.03 |
| CHEMBL3632703 | — | — | 1 | 5.96 |
| CHEMBL3632887 | — | — | 1 | 5.26 |
| CHEMBL3632702 | — | — | 1 | - |
| CHEMBL3632707 | — | — | 1 | - |
| CHEMBL3632708 | — | — | 1 | - |
| CHEMBL3632709 | — | — | 1 | - |
| CHEMBL3632710 | — | — | 1 | - |
| CHEMBL3632712 | — | — | 1 | - |
| CHEMBL3632714 | — | — | 1 | - |
| CHEMBL3632880 | — | — | 1 | - |
| CHEMBL3632890 | — | — | 1 | - |
| CHEMBL3632889 | — | — | 1 | - |
| CHEMBL3632888 | — | — | 1 | - |
| CHEMBL3632713 | — | — | 1 | - |
| CHEMBL3632885 | — | — | 1 | - |
| CHEMBL3632884 | — | — | 1 | - |
| CHEMBL3632883 | — | — | 1 | - |
| CHEMBL3392606 | — | — | 1 | - |
| CHEMBL2133303 | — | — | 1 | - |
| CHEMBL3632886 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237245 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3617852 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3632711 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3632882 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3632705 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3632881 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3632699 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3632706 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3632704 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2402207 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3632703 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3632887 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL484276 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632700 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632701 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632702 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632707 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632708 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632709 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632710 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632712 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632714 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632880 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632890 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632889 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632888 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632713 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632885 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632884 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632883 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3392606 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2133303 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3632886 | — | IC50 | > | 25000.0 | nM | - |