Assay Detail
Binding
CHEMBL3637193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human uPA by fluorescence based assay using L-PyroGlu-Gly-Arg-pNA.HCl as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.52 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3632759 | — | — | 1 | 5.89 |
| CHEMBL3632758 | — | — | 1 | 5.64 |
| CHEMBL284805 | — | — | 1 | 5.62 |
| CHEMBL3632760 | — | — | 1 | 5.57 |
| CHEMBL433501 | — | — | 1 | 5.26 |
| CHEMBL3632761 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3632759 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3632758 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL284805 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL3632760 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL433501 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL3632761 | — | Ki | = | 7800.0 | nM | 5.11 |