Assay Detail
Binding
CHEMBL3637200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human trypsin by fluorescence based assay using 25 uM Boc-Gln-Ala-Arg-7-amido-4-methyl coumarinhydrobromide as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.77 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3632759 | — | — | 1 | 6.40 |
| CHEMBL3632760 | — | — | 1 | 6.30 |
| CHEMBL3632755 | — | — | 1 | 6.10 |
| CHEMBL3632761 | — | — | 1 | 6.10 |
| CHEMBL284805 | — | — | 1 | 5.10 |
| CHEMBL433501 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3632759 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3632760 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL3632755 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL3632761 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL284805 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL433501 | — | Ki | = | 23000.0 | nM | 4.64 |