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Assay Detail

CHEMBL3637359

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Bacillus anthracis Lethal factor after 10 mins by mobility shift protease assay using 8 uM FITC as substrate
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Lethal factor (CHEMBL4372)
Type SINGLE PROTEIN
Organism Bacillus anthracis

Publication

Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
Kurbanov EK, Chiu TL, Solberg J, Francis S, Maize KM, Fernandez J, Johnson RL, Hawkinson JE, Walters MA, Finzel BC, Amin EA.
J Med Chem (2015) 58 : 8723 -8733
PubMed 26492514 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.37 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL201868 1 6.30
CHEMBL3634968 1 5.96
CHEMBL3634967 1 5.92
CHEMBL3634981 1 5.89
CHEMBL3634969 1 5.89
CHEMBL3634966 1 5.77
CHEMBL3634970 1 5.75
CHEMBL3634962 1 5.68
CHEMBL3634975 1 5.50
CHEMBL3634963 1 5.50
CHEMBL3634961 1 5.47
CHEMBL3634973 1 5.46
CHEMBL3634971 1 5.43
CHEMBL3634976 1 5.41
CHEMBL3634977 1 5.37
CHEMBL3634974 1 5.33
CHEMBL3634980 1 5.32
CHEMBL3634965 1 5.19
CHEMBL3634956 1 5.16
CHEMBL3634979 1 5.03
CHEMBL3634958 1 5.02
CHEMBL3634955 1 5.02
CHEMBL3634957 1 4.96
CHEMBL3634959 1 4.89
CHEMBL3634960 1 4.85
CHEMBL3634978 1 4.52
CHEMBL3634972 1 4.33
CHEMBL3634964 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL201868 IC50 = 500.0 nM 6.30
CHEMBL3634968 IC50 = 1100.0 nM 5.96
CHEMBL3634967 IC50 = 1200.0 nM 5.92
CHEMBL3634981 IC50 = 1300.0 nM 5.89
CHEMBL3634969 IC50 = 1300.0 nM 5.89
CHEMBL3634966 IC50 = 1700.0 nM 5.77
CHEMBL3634970 IC50 = 1800.0 nM 5.75
CHEMBL3634962 IC50 = 2100.0 nM 5.68
CHEMBL3634975 IC50 = 3200.0 nM 5.50
CHEMBL3634963 IC50 = 3200.0 nM 5.50
CHEMBL3634961 IC50 = 3400.0 nM 5.47
CHEMBL3634973 IC50 = 3500.0 nM 5.46
CHEMBL3634971 IC50 = 3700.0 nM 5.43
CHEMBL3634976 IC50 = 3900.0 nM 5.41
CHEMBL3634977 IC50 = 4300.0 nM 5.37
CHEMBL3634974 IC50 = 4700.0 nM 5.33
CHEMBL3634980 IC50 = 4800.0 nM 5.32
CHEMBL3634965 IC50 = 6400.0 nM 5.19
CHEMBL3634956 IC50 = 7000.0 nM 5.16
CHEMBL3634979 IC50 = 9300.0 nM 5.03
CHEMBL3634958 IC50 = 9500.0 nM 5.02
CHEMBL3634955 IC50 = 9600.0 nM 5.02
CHEMBL3634957 IC50 = 11000.0 nM 4.96
CHEMBL3634959 IC50 = 13000.0 nM 4.89
CHEMBL3634960 IC50 = 14000.0 nM 4.85
CHEMBL3634978 IC50 = 30000.0 nM 4.52
CHEMBL3634972 IC50 = 47000.0 nM 4.33
CHEMBL3634964 IC50 > 100000.0 nM -