Assay Detail
Functional
CHEMBL3637465
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Antiproliferative activity against human A549 cells after 2 days
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Developing structure-activity relationships from an HTS hit for inhibition of the Cks1-Skp2 protein-protein interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.21 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3633441 | — | — | 1 | 5.83 |
| CHEMBL3633428 | — | — | 1 | 5.53 |
| CHEMBL3633423 | — | — | 1 | 5.33 |
| CHEMBL3633440 | — | — | 1 | 5.23 |
| CHEMBL3633422 | — | — | 1 | 5.15 |
| CHEMBL3633420 | — | — | 1 | 5.14 |
| CHEMBL1487635 | — | — | 1 | 5.12 |
| CHEMBL3633439 | — | — | 1 | 5.10 |
| CHEMBL3633445 | — | — | 1 | 4.93 |
| CHEMBL3633429 | — | — | 1 | 4.77 |
| CHEMBL3633416 | — | — | 1 | - |
| CHEMBL3633421 | — | — | 1 | - |
| CHEMBL3633424 | — | — | 1 | - |
| CHEMBL3633430 | — | — | 1 | - |
| CHEMBL3633444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3633441 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL3633428 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL3633423 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL3633440 | — | IC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL3633422 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL3633420 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL1487635 | — | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL3633439 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL3633445 | — | IC50 | = | 11830.0 | nM | 4.93 |
| CHEMBL3633429 | — | IC50 | = | 16920.0 | nM | 4.77 |
| CHEMBL3633416 | — | IC50 | - | — | - | |
| CHEMBL3633421 | — | IC50 | - | — | - | |
| CHEMBL3633424 | — | IC50 | - | — | - | |
| CHEMBL3633430 | — | IC50 | - | — | - | |
| CHEMBL3633444 | — | IC50 | - | — | - |