Assay Detail
Binding
CHEMBL3637629
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Binding affinity to kappa opioid receptor (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.73 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3299005 | — | — | 1 | 8.03 |
| CHEMBL267495 | NALFURAFINE | 4.0 | 1 | 6.77 |
| CHEMBL58033 | (-)-U-50488 | — | 1 | 6.47 |
| CHEMBL603370 | — | — | 1 | 6.44 |
| CHEMBL3634396 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3299005 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL267495 | NALFURAFINE | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL58033 | (-)-U-50488 | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL603370 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL3634396 | — | Ki | = | 1200.0 | nM | 5.92 |