Assay Detail
Functional
CHEMBL3637733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay
14
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.99 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3634182 | — | — | 2 | 8.59 |
| CHEMBL435402 | — | — | 1 | 7.89 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | 7.62 |
| CHEMBL3634183 | — | — | 2 | 7.52 |
| CHEMBL3634185 | — | — | 1 | 7.43 |
| CHEMBL575257 | — | — | 2 | 7.10 |
| CHEMBL3634186 | — | — | 1 | 7.05 |
| CHEMBL3634184 | — | — | 2 | 6.14 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 6.07 |
| CHEMBL335206 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3634182 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL435402 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3634182 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3634183 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3634185 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL575257 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3634186 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL575257 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3634184 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3634184 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL335206 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL3634183 | — | EC50 | = | 1500.0 | nM | 5.82 |