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Assay Detail

CHEMBL3705050

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Binding
Inhibition Assay: Inhibition assay using beta-Secretase activity.
ChEMBL ↗
61
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-secretase 1 (CHEMBL4822) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aminodihydrothiazine derivatives
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 61 6.09 7.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3645171 — — 1 7.57
CHEMBL3645172 — — 1 7.50
CHEMBL3645168 — — 1 7.43
CHEMBL3642600 — — 1 7.41
CHEMBL3645166 — — 1 7.31
CHEMBL3645174 — — 1 7.27
CHEMBL3936271 — — 1 7.21
CHEMBL3642642 — — 1 6.89
CHEMBL3642623 — — 1 6.85
CHEMBL3642607 — — 1 6.83
CHEMBL3642611 — — 1 6.81
CHEMBL3645170 — — 1 6.80
CHEMBL3645164 — — 1 6.79
CHEMBL1589705 — — 1 6.78
CHEMBL3645163 — — 1 6.78
CHEMBL3645177 — — 1 6.76
CHEMBL3642639 — — 1 6.76
CHEMBL3642640 — — 1 6.66
CHEMBL3645167 — — 1 6.65
CHEMBL3642638 — — 1 6.64
CHEMBL3645165 — — 1 6.61
CHEMBL1601822 — — 1 6.58
CHEMBL3642604 — — 1 6.56
CHEMBL3645173 — — 1 6.36
CHEMBL3642614 — — 1 6.35
CHEMBL3645169 — — 1 6.30
CHEMBL3642619 — — 1 6.14
CHEMBL3642613 — — 1 6.09
CHEMBL3645175 — — 1 6.08
CHEMBL3642632 — — 1 6.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3645171 — IC50 = 27.0 nM 7.57
CHEMBL3645172 — IC50 = 32.0 nM 7.50
CHEMBL3645168 — IC50 = 37.0 nM 7.43
CHEMBL3642600 — IC50 = 39.4 nM 7.41
CHEMBL3645166 — IC50 = 49.0 nM 7.31
CHEMBL3645174 — IC50 = 54.0 nM 7.27
CHEMBL3936271 — IC50 = 61.0 nM 7.21
CHEMBL3642642 — IC50 = 130.0 nM 6.89
CHEMBL3642623 — IC50 = 140.0 nM 6.85
CHEMBL3642607 — IC50 = 149.0 nM 6.83
CHEMBL3642611 — IC50 = 156.0 nM 6.81
CHEMBL3645170 — IC50 = 160.0 nM 6.80
CHEMBL3645164 — IC50 = 163.0 nM 6.79
CHEMBL3645163 — IC50 = 165.0 nM 6.78
CHEMBL1589705 — IC50 = 165.0 nM 6.78
CHEMBL3645177 — IC50 = 174.0 nM 6.76
CHEMBL3642639 — IC50 = 175.0 nM 6.76
CHEMBL3642640 — IC50 = 220.0 nM 6.66
CHEMBL3645167 — IC50 = 222.0 nM 6.65
CHEMBL3642638 — IC50 = 229.0 nM 6.64
CHEMBL3645165 — IC50 = 243.0 nM 6.61
CHEMBL1601822 — IC50 = 264.0 nM 6.58
CHEMBL3642604 — IC50 = 278.0 nM 6.56
CHEMBL3645173 — IC50 = 435.0 nM 6.36
CHEMBL3642614 — IC50 = 450.0 nM 6.35
CHEMBL3645169 — IC50 = 505.0 nM 6.30
CHEMBL3642619 — IC50 = 720.0 nM 6.14
CHEMBL3642613 — IC50 = 816.0 nM 6.09
CHEMBL3645175 — IC50 = 833.0 nM 6.08
CHEMBL3642632 — IC50 = 912.0 nM 6.04
CHEMBL1610040 — IC50 = 930.0 nM 6.03
CHEMBL1312649 — IC50 = 1288.0 nM 5.89
CHEMBL3951035 — IC50 = 1479.0 nM 5.83
CHEMBL1526260 — IC50 = 1500.0 nM 5.82
CHEMBL1526260 — IC50 = 1500.0 nM 5.82
CHEMBL3642633 — IC50 = 1500.0 nM 5.82
CHEMBL3642630 — IC50 = 1977.0 nM 5.70
CHEMBL3645176 — IC50 = 2296.0 nM 5.64
CHEMBL3642641 — IC50 = 2278.0 nM 5.64
CHEMBL3907072 — IC50 = 2500.0 nM 5.60
CHEMBL3642618 — IC50 = 2563.0 nM 5.59
CHEMBL3642617 — IC50 = 2800.0 nM 5.55
CHEMBL3642601 — IC50 = 2900.0 nM 5.54
CHEMBL3642631 — IC50 = 3239.0 nM 5.49
CHEMBL3642636 — IC50 = 3642.0 nM 5.44
CHEMBL3642622 — IC50 = 4000.0 nM 5.40
CHEMBL3642615 — IC50 = 4500.0 nM 5.35
CHEMBL3642635 — IC50 = 4586.0 nM 5.34
CHEMBL3642603 — IC50 = 5000.0 nM 5.30
CHEMBL3642605 — IC50 = 5100.0 nM 5.29