Assay Detail
Binding
CHEMBL3705063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cellular Assay: ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways may be activated by ionising radiation, however only ATR is activated by UV. Since UV treatment is not practical for use in a high throught-put cell assay, the UV mimetic 4NQ0 (Sigma) was chosen to activate the ATR DNA damage response pathway.
27
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.52 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3648331 | — | — | 2 | 8.59 |
| CHEMBL3648329 | — | — | 1 | 8.15 |
| CHEMBL3648334 | — | — | 2 | 8.07 |
| CHEMBL3648341 | — | — | 2 | 8.00 |
| CHEMBL3648330 | — | — | 2 | 7.89 |
| CHEMBL3648333 | — | — | 1 | 7.86 |
| CHEMBL3648340 | — | — | 2 | 7.79 |
| CHEMBL3648328 | — | — | 2 | 7.66 |
| CHEMBL3648339 | — | — | 2 | 7.54 |
| CHEMBL3648338 | — | — | 2 | 7.48 |
| CHEMBL3648335 | — | — | 2 | 7.40 |
| CHEMBL3648336 | — | — | 1 | 7.29 |
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 7.23 |
| CHEMBL3648337 | — | — | 2 | 7.20 |
| CHEMBL3648332 | — | — | 2 | 6.96 |
| CHEMBL3648327 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3648331 | — | IC50 | = | 2.578 | nM | 8.59 |
| CHEMBL3648331 | — | IC50 | = | 2.757 | nM | 8.56 |
| CHEMBL3648329 | — | IC50 | = | 7.053 | nM | 8.15 |
| CHEMBL3648334 | — | IC50 | = | 8.428 | nM | 8.07 |
| CHEMBL3648341 | — | IC50 | = | 10.07 | nM | 8.00 |
| CHEMBL3648334 | — | IC50 | = | 12.79 | nM | 7.89 |
| CHEMBL3648330 | — | IC50 | = | 12.92 | nM | 7.89 |
| CHEMBL3648333 | — | IC50 | = | 13.76 | nM | 7.86 |
| CHEMBL3648340 | — | IC50 | = | 16.18 | nM | 7.79 |
| CHEMBL3648341 | — | IC50 | = | 17.96 | nM | 7.75 |
| CHEMBL3648340 | — | IC50 | = | 18.28 | nM | 7.74 |
| CHEMBL3648328 | — | IC50 | = | 21.82 | nM | 7.66 |
| CHEMBL3648339 | — | IC50 | = | 28.99 | nM | 7.54 |
| CHEMBL3648338 | — | IC50 | = | 33.13 | nM | 7.48 |
| CHEMBL3648335 | — | IC50 | = | 39.77 | nM | 7.40 |
| CHEMBL3648338 | — | IC50 | = | 44.4 | nM | 7.35 |
| CHEMBL3648339 | — | IC50 | = | 47.03 | nM | 7.33 |
| CHEMBL3648336 | — | IC50 | = | 51.12 | nM | 7.29 |
| CHEMBL3648335 | — | IC50 | = | 53.61 | nM | 7.27 |
| CHEMBL4285417 | CERALASERTIB | IC50 | = | 58.34 | nM | 7.23 |
| CHEMBL3648337 | — | IC50 | = | 62.55 | nM | 7.20 |
| CHEMBL3648337 | — | IC50 | = | 70.85 | nM | 7.15 |
| CHEMBL3648330 | — | IC50 | = | 75.77 | nM | 7.12 |
| CHEMBL3648332 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL3648332 | — | IC50 | = | 159.3 | nM | 6.80 |
| CHEMBL3648328 | — | IC50 | = | 235.5 | nM | 6.63 |
| CHEMBL3648327 | — | IC50 | = | 581.0 | nM | 6.24 |