Assay Detail
Binding
CHEMBL3705064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enzyme Assay: ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polycolonal antiserum raised to amino acids 400-480 of ATR (Tibbetts R S et, al, 1999, GenesDev.13:152-157).
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.05 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 8.43 |
| CHEMBL3648329 | — | — | 1 | 8.25 |
| CHEMBL3648327 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285417 | CERALASERTIB | IC50 | = | 3.747 | nM | 8.43 |
| CHEMBL3648329 | — | IC50 | = | 5.607 | nM | 8.25 |
| CHEMBL3648327 | — | IC50 | = | 34.03 | nM | 7.47 |