Assay Detail
Binding
CHEMBL3705104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In Vitro Assay: The inhibitory activity of the compounds of this invention against the SGLT-1 or SGLT-2 transporters.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SGLT-2 inhibitors, methods of making them, and uses thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.82 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3660003 | — | — | 1 | 7.94 |
| CHEMBL3639588 | — | — | 1 | 7.63 |
| CHEMBL3288752 | — | — | 1 | 7.44 |
| CHEMBL3288738 | — | — | 1 | 7.09 |
| CHEMBL3288737 | — | — | 1 | 7.08 |
| CHEMBL3288744 | — | — | 1 | 7.04 |
| CHEMBL3288739 | — | — | 1 | 7.02 |
| CHEMBL3288745 | — | — | 1 | 6.96 |
| CHEMBL3288740 | — | — | 1 | 6.89 |
| CHEMBL3288741 | — | — | 1 | 6.84 |
| CHEMBL3660004 | — | — | 1 | 6.83 |
| CHEMBL3659998 | — | — | 1 | 6.77 |
| CHEMBL3288742 | — | — | 1 | 6.65 |
| CHEMBL3659997 | — | — | 1 | 6.65 |
| CHEMBL3660000 | — | — | 1 | 6.65 |
| CHEMBL3288746 | — | — | 1 | 6.56 |
| CHEMBL3659996 | — | — | 1 | 6.50 |
| CHEMBL3660002 | — | — | 1 | 6.48 |
| CHEMBL3659999 | — | — | 1 | 6.33 |
| CHEMBL3660005 | — | — | 1 | 6.31 |
| CHEMBL3660001 | — | — | 1 | 6.27 |
| CHEMBL3288743 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3660003 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL3639588 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL3288752 | — | IC50 | = | 36.6 | nM | 7.44 |
| CHEMBL3288738 | — | IC50 | = | 81.1 | nM | 7.09 |
| CHEMBL3288737 | — | IC50 | = | 82.8 | nM | 7.08 |
| CHEMBL3288744 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3288739 | — | IC50 | = | 94.8 | nM | 7.02 |
| CHEMBL3288745 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL3288740 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL3288741 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL3660004 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3659998 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3288742 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL3659997 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL3660000 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL3288746 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL3659996 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL3660002 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL3659999 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL3660005 | — | IC50 | = | 489.0 | nM | 6.31 |
| CHEMBL3660001 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL3288743 | — | IC50 | = | 991.0 | nM | 6.00 |