Assay Detail
Binding
CHEMBL3705151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enzyme Assay: Enzyme assay using dipeptidyl peptidase-IV.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.76 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3645497 | — | — | 1 | 9.00 |
| CHEMBL3645494 | — | — | 1 | 8.89 |
| CHEMBL3645493 | — | — | 1 | 8.80 |
| CHEMBL3645495 | — | — | 1 | 8.80 |
| CHEMBL3645496 | — | — | 1 | 8.72 |
| CHEMBL3645491 | — | — | 1 | 8.66 |
| CHEMBL3645490 | — | — | 1 | 8.60 |
| CHEMBL3645492 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3645497 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3645494 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3645493 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3645495 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3645496 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3645491 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3645490 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3645492 | — | IC50 | = | 2.6 | nM | 8.59 |