Assay Detail
Binding
CHEMBL3705271
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Spectrophotometric Assay: Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.
112
Total Activities
111
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Klebsiella pneumoniae |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Œ=-lactamase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 112 | 7.15 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3892741 | — | — | 1 | 8.80 |
| CHEMBL3935623 | — | — | 1 | 8.70 |
| CHEMBL3932731 | — | — | 1 | 8.52 |
| CHEMBL3938261 | — | — | 1 | 8.40 |
| CHEMBL3958929 | — | — | 1 | 8.40 |
| CHEMBL3957170 | — | — | 1 | 8.22 |
| CHEMBL3913753 | — | — | 1 | 8.10 |
| CHEMBL3981884 | — | — | 1 | 8.10 |
| CHEMBL3946631 | — | — | 1 | 8.10 |
| CHEMBL3941136 | — | — | 1 | 8.10 |
| CHEMBL3112755 | — | — | 1 | 8.05 |
| CHEMBL3932241 | — | — | 1 | 8.05 |
| CHEMBL3953568 | — | — | 1 | 8.00 |
| CHEMBL3972003 | — | — | 1 | 8.00 |
| CHEMBL3112751 | — | — | 1 | 8.00 |
| CHEMBL3961606 | — | — | 1 | 8.00 |
| CHEMBL3975378 | — | — | 1 | 7.96 |
| CHEMBL3963057 | — | — | 1 | 7.96 |
| CHEMBL3949467 | — | — | 1 | 7.96 |
| CHEMBL3112591 | — | — | 1 | 7.96 |
| CHEMBL3947548 | — | — | 1 | 7.92 |
| CHEMBL3899991 | — | — | 1 | 7.89 |
| CHEMBL3944458 | — | — | 1 | 7.89 |
| CHEMBL3963657 | — | — | 1 | 7.82 |
| CHEMBL3986788 | — | — | 1 | 7.82 |
| CHEMBL3919215 | — | — | 1 | 7.77 |
| CHEMBL3964136 | — | — | 1 | 7.77 |
| CHEMBL3956371 | — | — | 1 | 7.75 |
| CHEMBL3956247 | — | — | 1 | 7.72 |
| CHEMBL3896059 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3892741 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3935623 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3932731 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3958929 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3938261 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3957170 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3981884 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3913753 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3941136 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3946631 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3112755 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3932241 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3953568 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3972003 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3112751 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3961606 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3112591 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3949467 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3963057 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3975378 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3947548 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3899991 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3944458 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3986788 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3963657 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3919215 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3964136 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3956371 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3896059 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3956247 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3939469 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3922005 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3931511 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3890757 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3922994 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3895684 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3981837 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3959746 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3902510 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3934106 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3934406 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3895019 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3931678 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3112748 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3961665 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3896225 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3951105 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3900778 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3112747 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3112749 | — | IC50 | = | 42.0 | nM | 7.38 |