Assay Detail
Binding
CHEMBL3705301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In Vitro Assay: In vitro inhibition assay of Chymase.
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azaquinazolinediones chymase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.44 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3640120 | — | — | 1 | 9.52 |
| CHEMBL3640116 | BI-1942 | — | 1 | 9.40 |
| CHEMBL3640115 | — | — | 1 | 9.15 |
| CHEMBL3640118 | — | — | 1 | 9.15 |
| CHEMBL3640105 | — | — | 1 | 9.05 |
| CHEMBL3640121 | — | — | 1 | 8.89 |
| CHEMBL3640119 | — | — | 1 | 8.85 |
| CHEMBL3640110 | — | — | 1 | 8.85 |
| CHEMBL3640102 | — | — | 1 | 8.68 |
| CHEMBL3640111 | — | — | 1 | 8.66 |
| CHEMBL3639389 | — | — | 1 | 8.60 |
| CHEMBL3640100 | — | — | 1 | 8.59 |
| CHEMBL3640114 | — | — | 1 | 8.59 |
| CHEMBL3640117 | — | — | 1 | 8.57 |
| CHEMBL3640107 | — | — | 1 | 8.52 |
| CHEMBL3640095 | — | — | 1 | 8.51 |
| CHEMBL3640103 | — | — | 1 | 8.40 |
| CHEMBL3640104 | — | — | 1 | 8.32 |
| CHEMBL3640106 | — | — | 1 | 8.21 |
| CHEMBL3640094 | — | — | 1 | 8.21 |
| CHEMBL3640101 | — | — | 1 | 8.15 |
| CHEMBL3640099 | — | — | 1 | 8.15 |
| CHEMBL3640113 | — | — | 1 | 8.13 |
| CHEMBL3640097 | — | — | 1 | 8.10 |
| CHEMBL3640093 | — | — | 1 | 8.02 |
| CHEMBL3640109 | — | — | 1 | 8.00 |
| CHEMBL3640096 | — | — | 1 | 7.96 |
| CHEMBL3640098 | — | — | 1 | 7.77 |
| CHEMBL3640108 | — | — | 1 | 7.70 |
| CHEMBL3640112 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3640120 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3640116 | BI-1942 | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3640115 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3640118 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3640105 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3640121 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3640119 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3640110 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3640102 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3640111 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3639389 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3640100 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3640114 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3640117 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3640107 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3640095 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3640103 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3640104 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3640106 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3640094 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3640101 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3640099 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3640113 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3640097 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3640093 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL3640109 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL3640096 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3640098 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3640108 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3640112 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3640092 | — | IC50 | = | 36.0 | nM | 7.44 |