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Assay Detail

CHEMBL3705306

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In Vitro Enzyme Assay: The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) assay system.
ChEMBL ↗
349
Total Activities
347
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Focal adhesion kinase 1 (CHEMBL2695) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 349 5.72 7.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3642370 — — 1 7.94
CHEMBL3642373 — — 1 7.89
CHEMBL3642372 — — 1 7.87
CHEMBL3642371 — — 1 7.83
CHEMBL3642388 — — 1 7.75
CHEMBL3642420 — — 1 7.74
CHEMBL3642416 — — 1 7.66
CHEMBL3642345 — — 1 7.52
CHEMBL3642360 — — 1 7.40
CHEMBL3642415 — — 1 7.38
CHEMBL3642387 — — 1 7.32
CHEMBL3642347 — — 1 7.22
CHEMBL3642406 — — 1 7.20
CHEMBL3642359 — — 1 7.15
CHEMBL3642346 — — 1 7.11
CHEMBL3642364 — — 1 7.00
CHEMBL3642369 — — 1 6.98
CHEMBL3642363 — — 1 6.91
CHEMBL3644974 — — 1 6.87
CHEMBL3642421 — — 1 6.78
CHEMBL3642288 — — 1 6.77
CHEMBL3642314 — — 1 6.76
CHEMBL3642379 — — 1 6.75
CHEMBL3642422 — — 1 6.72
CHEMBL3642361 — — 1 6.70
CHEMBL3642362 — — 1 6.70
CHEMBL3642256 — — 1 6.69
CHEMBL3642358 — — 1 6.67
CHEMBL3642305 — — 1 6.64
CHEMBL3642286 — — 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3642370 — IC50 = 11.39 nM 7.94
CHEMBL3642373 — IC50 = 12.96 nM 7.89
CHEMBL3642372 — IC50 = 13.58 nM 7.87
CHEMBL3642371 — IC50 = 14.63 nM 7.83
CHEMBL3642388 — IC50 = 17.76 nM 7.75
CHEMBL3642420 — IC50 = 18.18 nM 7.74
CHEMBL3642416 — IC50 = 21.81 nM 7.66
CHEMBL3642345 — IC50 = 29.99 nM 7.52
CHEMBL3642360 — IC50 = 39.71 nM 7.40
CHEMBL3642415 — IC50 = 41.73 nM 7.38
CHEMBL3642387 — IC50 = 48.13 nM 7.32
CHEMBL3642347 — IC50 = 59.73 nM 7.22
CHEMBL3642406 — IC50 = 62.53 nM 7.20
CHEMBL3642359 — IC50 = 71.08 nM 7.15
CHEMBL3642346 — IC50 = 77.33 nM 7.11
CHEMBL3642364 — IC50 = 98.78 nM 7.00
CHEMBL3642369 — IC50 = 105.75 nM 6.98
CHEMBL3642363 — IC50 = 123.79 nM 6.91
CHEMBL3644974 — IC50 = 135.43 nM 6.87
CHEMBL3642421 — IC50 = 167.28 nM 6.78
CHEMBL3642288 — IC50 = 168.3 nM 6.77
CHEMBL3642314 — IC50 = 173.0 nM 6.76
CHEMBL3642379 — IC50 = 178.99 nM 6.75
CHEMBL3642422 — IC50 = 189.47 nM 6.72
CHEMBL3642362 — IC50 = 200.46 nM 6.70
CHEMBL3642361 — IC50 = 199.46 nM 6.70
CHEMBL3642256 — IC50 = 205.8 nM 6.69
CHEMBL3642358 — IC50 = 215.11 nM 6.67
CHEMBL3642305 — IC50 = 226.9 nM 6.64
CHEMBL3642286 — IC50 = 250.7 nM 6.60
CHEMBL3642315 — IC50 = 263.5 nM 6.58
CHEMBL2062809 — IC50 = 265.1 nM 6.58
CHEMBL3642381 — IC50 = 276.37 nM 6.56
CHEMBL3642302 — IC50 = 291.0 nM 6.54
CHEMBL3642380 — IC50 = 299.53 nM 6.52
CHEMBL3642289 — IC50 = 306.4 nM 6.51
CHEMBL3642316 — IC50 = 341.2 nM 6.47
CHEMBL3642306 — IC50 = 359.4 nM 6.44
CHEMBL3642405 — IC50 = 384.26 nM 6.42
CHEMBL3642378 — IC50 = 379.27 nM 6.42
CHEMBL3642304 — IC50 = 379.8 nM 6.42
CHEMBL2062805 — IC50 = 410.2 nM 6.39
CHEMBL2414547 — IC50 = 421.2 nM 6.38
CHEMBL3645084 — IC50 = 422.01 nM 6.38
CHEMBL3645089 — IC50 = 434.28 nM 6.36
CHEMBL3642258 — IC50 = 434.0 nM 6.36
CHEMBL3645085 — IC50 = 442.65 nM 6.35
CHEMBL2062803 — IC50 = 461.2 nM 6.34
CHEMBL3644989 — IC50 = 481.21 nM 6.32
CHEMBL3642303 — IC50 = 502.4 nM 6.30