Assay Detail
Binding
CHEMBL3705335
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding Assay: Binding assay of certain compounds of this invention to the opioid receptor was determine using radioligand binding assay (screening and dose-displacement).
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Opioid growth factor receptor-like protein 1 (CHEMBL3638334) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Buprenophine analogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.72 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3916122 | — | — | 1 | 6.27 |
| CHEMBL3664525 | — | — | 1 | 6.25 |
| CHEMBL3923372 | — | — | 1 | 6.08 |
| CHEMBL3908275 | — | — | 1 | 5.99 |
| CHEMBL3907149 | — | — | 1 | 5.95 |
| CHEMBL3912511 | — | — | 1 | 5.93 |
| CHEMBL3664541 | — | — | 1 | 5.89 |
| CHEMBL3893577 | — | — | 1 | 5.79 |
| CHEMBL3955920 | — | — | 1 | 5.59 |
| CHEMBL3904663 | — | — | 1 | 5.40 |
| CHEMBL3911529 | — | — | 1 | 5.34 |
| CHEMBL3901699 | — | — | 1 | 5.02 |
| CHEMBL3948231 | — | — | 1 | 4.86 |
| CHEMBL3948400 | — | — | 1 | - |
| CHEMBL3954498 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3916122 | — | Ki | = | 532.0 | nM | 6.27 |
| CHEMBL3664525 | — | Ki | = | 569.0 | nM | 6.25 |
| CHEMBL3923372 | — | Ki | = | 823.29 | nM | 6.08 |
| CHEMBL3908275 | — | Ki | = | 1034.67 | nM | 5.99 |
| CHEMBL3907149 | — | Ki | = | 1116.98 | nM | 5.95 |
| CHEMBL3912511 | — | Ki | = | 1165.91 | nM | 5.93 |
| CHEMBL3664541 | — | Ki | = | 1295.55 | nM | 5.89 |
| CHEMBL3893577 | — | Ki | = | 1602.42 | nM | 5.79 |
| CHEMBL3955920 | — | Ki | = | 2571.83 | nM | 5.59 |
| CHEMBL3904663 | — | Ki | = | 3957.55 | nM | 5.40 |
| CHEMBL3911529 | — | Ki | = | 4555.05 | nM | 5.34 |
| CHEMBL3901699 | — | Ki | = | 9605.7 | nM | 5.02 |
| CHEMBL3948231 | — | Ki | = | 13803.96 | nM | 4.86 |
| CHEMBL3948400 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL3954498 | — | Ki | > | 20000.0 | nM | - |