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Assay Detail

CHEMBL3705344

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Binding
In Vitro Inhibition Assay: JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.
ChEMBL ↗
106
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 8 (CHEMBL2276) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of JNK
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 106 7.46 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3674700 — — 2 8.70
CHEMBL3674715 — — 2 8.62
CHEMBL3674690 — — 2 8.52
CHEMBL2392825 — — 2 8.52
CHEMBL2392833 — — 2 8.51
CHEMBL3674695 — — 2 8.44
CHEMBL3674691 — — 2 8.44
CHEMBL3674724 — — 2 8.44
CHEMBL3674699 — — 2 8.43
CHEMBL3674698 — — 2 8.38
CHEMBL3674727 — — 2 8.36
CHEMBL3674711 — — 2 8.31
CHEMBL2392827 — — 2 8.27
CHEMBL2392832 — — 2 8.24
CHEMBL3674693 — — 2 8.21
CHEMBL2392834 — — 2 8.18
CHEMBL2392837 — — 2 8.17
CHEMBL2392838 — — 2 8.08
CHEMBL2392835 — — 2 8.07
CHEMBL3674728 — — 2 8.04
CHEMBL3674704 — — 2 8.02
CHEMBL2392828 — — 2 8.00
CHEMBL3674686 — — 2 7.99
CHEMBL3674689 — — 2 7.98
CHEMBL3674692 — — 2 7.93
CHEMBL2392840 — — 1 7.93
CHEMBL3674705 — — 2 7.91
CHEMBL3674735 — — 2 7.91
CHEMBL3674736 — — 1 7.86
CHEMBL3674688 — — 2 7.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3674700 — IC50 = 2.0 nM 8.70
CHEMBL3674715 — IC50 = 2.4 nM 8.62
CHEMBL3674690 — IC50 = 3.0 nM 8.52
CHEMBL2392825 — IC50 = 3.0 nM 8.52
CHEMBL2392833 — IC50 = 3.1 nM 8.51
CHEMBL3674691 — IC50 = 3.6 nM 8.44
CHEMBL3674695 — IC50 = 3.6 nM 8.44
CHEMBL3674724 — IC50 = 3.6 nM 8.44
CHEMBL3674699 — IC50 = 3.7 nM 8.43
CHEMBL3674698 — IC50 = 4.2 nM 8.38
CHEMBL3674727 — IC50 = 4.4 nM 8.36
CHEMBL3674711 — IC50 = 4.9 nM 8.31
CHEMBL2392827 — IC50 = 5.4 nM 8.27
CHEMBL2392832 — IC50 = 5.8 nM 8.24
CHEMBL3674693 — IC50 = 6.1 nM 8.21
CHEMBL3674724 — IC50 = 6.2 nM 8.21
CHEMBL2392834 — IC50 = 6.6 nM 8.18
CHEMBL2392837 — IC50 = 6.8 nM 8.17
CHEMBL2392838 — IC50 = 8.3 nM 8.08
CHEMBL2392835 — IC50 = 8.5 nM 8.07
CHEMBL3674728 — IC50 = 9.2 nM 8.04
CHEMBL3674704 — IC50 = 9.6 nM 8.02
CHEMBL2392828 — IC50 = 10.0 nM 8.00
CHEMBL3674686 — IC50 = 10.3 nM 7.99
CHEMBL3674689 — IC50 = 10.4 nM 7.98
CHEMBL3674692 — IC50 = 11.7 nM 7.93
CHEMBL2392840 — IC50 = 11.7 nM 7.93
CHEMBL3674705 — IC50 = 12.4 nM 7.91
CHEMBL3674735 — IC50 = 12.4 nM 7.91
CHEMBL3674700 — IC50 = 12.8 nM 7.89
CHEMBL3674715 — IC50 = 13.6 nM 7.87
CHEMBL3674736 — IC50 = 13.9 nM 7.86
CHEMBL3674688 — IC50 = 14.0 nM 7.85
CHEMBL3674726 — IC50 = 15.2 nM 7.82
CHEMBL3674723 — IC50 = 15.6 nM 7.81
CHEMBL3674729 — IC50 = 15.9 nM 7.80
CHEMBL2392832 — IC50 = 16.7 nM 7.78
CHEMBL2392833 — IC50 = 17.9 nM 7.75
CHEMBL3674728 — IC50 = 18.7 nM 7.73
CHEMBL3674690 — IC50 = 19.2 nM 7.72
CHEMBL3674717 — IC50 = 19.2 nM 7.72
CHEMBL3674687 — IC50 = 19.1 nM 7.72
CHEMBL3674691 — IC50 = 20.8 nM 7.68
CHEMBL3674725 — IC50 = 21.8 nM 7.66
CHEMBL3674727 — IC50 = 23.1 nM 7.64
CHEMBL2392825 — IC50 = 23.5 nM 7.63
CHEMBL3674699 — IC50 = 24.6 nM 7.61
CHEMBL3674714 — IC50 = 25.0 nM 7.60
CHEMBL3674735 — IC50 = 25.7 nM 7.59
CHEMBL3674698 — IC50 = 25.6 nM 7.59