Assay Detail
Binding
CHEMBL3705355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition Assay: Inhibition assay using hSGLT2.
97
Total Activities
97
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
C-aryl glucoside SGLT2 inhibitors and pharmaceutical compositions comprising same
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 97 | 6.92 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601510 | — | — | 1 | 8.46 |
| CHEMBL591949 | — | — | 1 | 8.39 |
| CHEMBL3679709 | — | — | 1 | 8.26 |
| CHEMBL605905 | — | — | 1 | 8.15 |
| CHEMBL590992 | — | — | 1 | 7.97 |
| CHEMBL3639785 | — | — | 1 | 7.97 |
| CHEMBL591739 | — | — | 1 | 7.96 |
| CHEMBL1083975 | — | — | 1 | 7.94 |
| CHEMBL1085771 | — | — | 1 | 7.87 |
| CHEMBL606750 | — | — | 1 | 7.84 |
| CHEMBL603167 | — | — | 1 | 7.78 |
| CHEMBL1085547 | — | — | 1 | 7.77 |
| CHEMBL1085769 | — | — | 1 | 7.76 |
| CHEMBL3679708 | — | — | 1 | 7.75 |
| CHEMBL590751 | — | — | 1 | 7.75 |
| CHEMBL590020 | — | — | 1 | 7.74 |
| CHEMBL590271 | — | — | 1 | 7.66 |
| CHEMBL3679706 | — | — | 1 | 7.61 |
| CHEMBL3679704 | — | — | 1 | 7.60 |
| CHEMBL590041 | — | — | 1 | 7.60 |
| CHEMBL590296 | — | — | 1 | 7.52 |
| CHEMBL600982 | — | — | 1 | 7.44 |
| CHEMBL1083690 | — | — | 1 | 7.37 |
| CHEMBL590021 | — | — | 1 | 7.35 |
| CHEMBL590042 | — | — | 1 | 7.34 |
| CHEMBL3679698 | — | — | 1 | 7.30 |
| CHEMBL601465 | — | — | 1 | 7.28 |
| CHEMBL590991 | — | — | 1 | 7.23 |
| CHEMBL1083978 | — | — | 1 | 7.21 |
| CHEMBL1085272 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601510 | — | IC50 | = | 3.51 | nM | 8.46 |
| CHEMBL591949 | — | IC50 | = | 4.06 | nM | 8.39 |
| CHEMBL3679709 | — | IC50 | = | 5.55 | nM | 8.26 |
| CHEMBL605905 | — | IC50 | = | 7.03 | nM | 8.15 |
| CHEMBL590992 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL3639785 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL591739 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL1083975 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL1085771 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL606750 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL603167 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL1085547 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1085769 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL590751 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL3679708 | — | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL590020 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL590271 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL3679706 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL3679704 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL590041 | — | IC50 | = | 24.9 | nM | 7.60 |
| CHEMBL590296 | — | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL600982 | — | IC50 | = | 36.4 | nM | 7.44 |
| CHEMBL1083690 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL590021 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL590042 | — | IC50 | = | 45.3 | nM | 7.34 |
| CHEMBL3679698 | — | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL601465 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL590991 | — | IC50 | = | 58.3 | nM | 7.23 |
| CHEMBL1083978 | — | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL1085272 | — | IC50 | = | 64.9 | nM | 7.19 |
| CHEMBL1083674 | — | IC50 | = | 64.3 | nM | 7.19 |
| CHEMBL1086441 | — | IC50 | = | 71.3 | nM | 7.15 |
| CHEMBL1084166 | — | IC50 | = | 71.4 | nM | 7.15 |
| CHEMBL1085297 | — | IC50 | = | 70.8 | nM | 7.15 |
| CHEMBL3679691 | — | IC50 | = | 72.6 | nM | 7.14 |
| CHEMBL1084440 | — | IC50 | = | 75.4 | nM | 7.12 |
| CHEMBL1086192 | — | IC50 | = | 77.6 | nM | 7.11 |
| CHEMBL589300 | — | IC50 | = | 81.6 | nM | 7.09 |
| CHEMBL1084258 | — | IC50 | = | 82.7 | nM | 7.08 |
| CHEMBL3679705 | — | IC50 | = | 88.9 | nM | 7.05 |
| CHEMBL590514 | — | IC50 | = | 97.4 | nM | 7.01 |
| CHEMBL1084259 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL606689 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL590752 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL1085770 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL1085544 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1085545 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL592686 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL589324 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL602524 | — | IC50 | = | 126.0 | nM | 6.90 |