Assay Detail
Binding
CHEMBL3705630
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enzyme Assay-Time Dependence: Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay that couples the production of glutamate (liberated by GAC) to glutamate dehydrogenase (GDH) and measuring the change in absorbance for the reduction of NAD+ to NADH.
330
Total Activities
326
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminase kidney isoform, mitochondrial (CHEMBL2146302) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Heterocyclic inhibitors of glutaminase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 330 | 7.86 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3675017 | — | — | 1 | 8.70 |
| CHEMBL3675018 | — | — | 1 | 8.70 |
| CHEMBL3675020 | — | — | 1 | 8.70 |
| CHEMBL3675057 | — | — | 1 | 8.70 |
| CHEMBL3675059 | — | — | 1 | 8.70 |
| CHEMBL3680041 | — | — | 1 | 8.70 |
| CHEMBL3675079 | — | — | 1 | 8.52 |
| CHEMBL3675055 | — | — | 1 | 8.52 |
| CHEMBL3675081 | — | — | 1 | 8.52 |
| CHEMBL3675099 | — | — | 1 | 8.52 |
| CHEMBL3675100 | — | — | 1 | 8.52 |
| CHEMBL3675141 | — | — | 2 | 8.52 |
| CHEMBL3675140 | — | — | 1 | 8.52 |
| CHEMBL3675150 | — | — | 1 | 8.52 |
| CHEMBL3675153 | — | — | 1 | 8.52 |
| CHEMBL3679964 | — | — | 1 | 8.52 |
| CHEMBL3679978 | — | — | 1 | 8.52 |
| CHEMBL3675067 | — | — | 1 | 8.52 |
| CHEMBL3675058 | — | — | 1 | 8.52 |
| CHEMBL3675054 | — | — | 1 | 8.52 |
| CHEMBL3675043 | — | — | 1 | 8.52 |
| CHEMBL3675041 | — | — | 1 | 8.52 |
| CHEMBL3675040 | — | — | 1 | 8.52 |
| CHEMBL3675038 | — | — | 1 | 8.52 |
| CHEMBL3675036 | — | — | 1 | 8.52 |
| CHEMBL3675029 | — | — | 1 | 8.52 |
| CHEMBL3674970 | — | — | 1 | 8.52 |
| CHEMBL3674968 | — | — | 1 | 8.52 |
| CHEMBL3674980 | — | — | 1 | 8.40 |
| CHEMBL3674981 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3675057 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3675059 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3675020 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3680041 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3675018 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3675017 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3675081 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675029 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675079 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3679964 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3674968 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675036 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3674970 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3679978 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675038 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675040 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675041 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675153 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675043 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675140 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675141 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675058 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675055 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675054 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675099 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675100 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675150 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675067 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3675117 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675121 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3679985 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675120 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675080 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675068 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3679965 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3679971 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3674980 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3674981 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675155 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675154 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675154 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675069 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675151 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3674983 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675014 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3679966 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675134 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675142 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3679967 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3675167 | — | IC50 | = | 4.0 | nM | 8.40 |