Assay Detail
Binding
CHEMBL3707574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Kinase Assay: The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory concentration (IC50) values determined by Millipore UK Ltd; Gemini Crescent; Dundee Technology Park; Dundee DD2 1SW; UK (IC50Profiler). Detailed protocols can be found at: www.millipore.com/drugdiscovery/dd3/assayprotocols.
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.40 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3699444 | — | — | 1 | 6.62 |
| CHEMBL201511 | MALEIMIDE | — | 1 | 6.57 |
| CHEMBL3699443 | — | — | 1 | 6.32 |
| CHEMBL3699446 | — | — | 2 | 6.26 |
| CHEMBL3699445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3699444 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL201511 | MALEIMIDE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3699443 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3699446 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL3699446 | — | IC50 | = | 556.0 | nM | 6.25 |
| CHEMBL3699445 | — | IC50 | > | 1000.0 | nM | - |