Assay Detail
Binding
CHEMBL3707622
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ELISA Assay: An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM27 in the culture medium.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.29 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3688201 | — | — | 1 | 8.52 |
| CHEMBL3688205 | — | — | 1 | 8.40 |
| CHEMBL3688199 | — | — | 1 | 8.20 |
| CHEMBL3688200 | — | — | 1 | 7.80 |
| CHEMBL3688202 | — | — | 1 | 7.70 |
| CHEMBL3688206 | — | — | 1 | 7.52 |
| CHEMBL3688210 | — | — | 1 | 7.28 |
| CHEMBL3688208 | — | — | 1 | 7.21 |
| CHEMBL3688212 | — | — | 1 | 7.11 |
| CHEMBL3688204 | — | — | 1 | 6.85 |
| CHEMBL3688203 | — | — | 1 | 6.77 |
| CHEMBL3688211 | — | — | 1 | 6.58 |
| CHEMBL3688207 | — | — | 1 | 6.52 |
| CHEMBL3688209 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3688201 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3688205 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3688199 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3688200 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3688202 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3688206 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3688210 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3688208 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3688212 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3688204 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3688203 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3688211 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3688207 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3688209 | — | IC50 | = | 2290.0 | nM | 5.64 |