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Assay Detail

CHEMBL3707646

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Binding
Inhibition Assay: The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.
ChEMBL ↗
117
Total Activities
117
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase JAK2 (CHEMBL2971) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of JAK
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 117 9.88 10.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3665130 — — 1 10.97
CHEMBL3665128 — — 1 10.97
CHEMBL3665202 — — 1 10.76
CHEMBL3665129 — — 1 10.72
CHEMBL3665180 — — 1 10.71
CHEMBL3665176 — — 1 10.70
CHEMBL3665131 — — 1 10.68
CHEMBL3665199 — — 1 10.66
CHEMBL3665123 — — 1 10.64
CHEMBL3335690 — — 1 10.61
CHEMBL3665127 — — 1 10.56
CHEMBL3665122 — — 1 10.53
CHEMBL3665188 — — 1 10.53
CHEMBL3665119 — — 1 10.53
CHEMBL3665222 — — 1 10.48
CHEMBL3665147 — — 1 10.46
CHEMBL3357978 — — 1 10.44
CHEMBL3665172 — — 1 10.44
CHEMBL3665173 — — 1 10.42
CHEMBL3665126 — — 1 10.40
CHEMBL3665174 — — 1 10.40
CHEMBL3665152 — — 1 10.38
CHEMBL3665200 — — 1 10.36
CHEMBL3665124 — — 1 10.33
CHEMBL3665146 — — 1 10.33
CHEMBL3665184 — — 1 10.31
CHEMBL3665206 — — 1 10.31
CHEMBL3335696 — — 1 10.27
CHEMBL3665181 — — 1 10.26
CHEMBL3665179 — — 1 10.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3665130 — IC50 = 0.0106 nM 10.97
CHEMBL3665128 — IC50 = 0.0108 nM 10.97
CHEMBL3665202 — IC50 = 0.0172 nM 10.76
CHEMBL3665129 — IC50 = 0.0191 nM 10.72
CHEMBL3665180 — IC50 = 0.0196 nM 10.71
CHEMBL3665176 — IC50 = 0.0201 nM 10.70
CHEMBL3665131 — IC50 = 0.0209 nM 10.68
CHEMBL3665199 — IC50 = 0.0221 nM 10.66
CHEMBL3665123 — IC50 = 0.0228 nM 10.64
CHEMBL3335690 — IC50 = 0.0245 nM 10.61
CHEMBL3665127 — IC50 = 0.0276 nM 10.56
CHEMBL3665122 — IC50 = 0.0296 nM 10.53
CHEMBL3665188 — IC50 = 0.0293 nM 10.53
CHEMBL3665119 — IC50 = 0.0292 nM 10.53
CHEMBL3665222 — IC50 = 0.0332 nM 10.48
CHEMBL3665147 — IC50 = 0.035 nM 10.46
CHEMBL3357978 — IC50 = 0.0359 nM 10.44
CHEMBL3665172 — IC50 = 0.0367 nM 10.44
CHEMBL3665173 — IC50 = 0.0384 nM 10.42
CHEMBL3665126 — IC50 = 0.0397 nM 10.40
CHEMBL3665174 — IC50 = 0.0398 nM 10.40
CHEMBL3665152 — IC50 = 0.0413 nM 10.38
CHEMBL3665200 — IC50 = 0.0432 nM 10.36
CHEMBL3665124 — IC50 = 0.047 nM 10.33
CHEMBL3665146 — IC50 = 0.0464 nM 10.33
CHEMBL3665206 — IC50 = 0.0485 nM 10.31
CHEMBL3665184 — IC50 = 0.049 nM 10.31
CHEMBL3335696 — IC50 = 0.054 nM 10.27
CHEMBL3665181 — IC50 = 0.0549 nM 10.26
CHEMBL3665179 — IC50 = 0.0581 nM 10.24
CHEMBL3665214 — IC50 = 0.0585 nM 10.23
CHEMBL3335699 — IC50 = 0.0603 nM 10.22
CHEMBL3665182 — IC50 = 0.0646 nM 10.19
CHEMBL3665192 — IC50 = 0.0668 nM 10.18
CHEMBL3665142 — IC50 = 0.0676 nM 10.17
CHEMBL3665213 — IC50 = 0.0708 nM 10.15
CHEMBL3335692 — IC50 = 0.07 nM 10.15
CHEMBL3335694 — IC50 = 0.0713 nM 10.15
CHEMBL3665189 — IC50 = 0.0717 nM 10.14
CHEMBL3665183 — IC50 = 0.0764 nM 10.12
CHEMBL3665125 — IC50 = 0.0765 nM 10.12
CHEMBL3665193 — IC50 = 0.0763 nM 10.12
CHEMBL3665216 — IC50 = 0.0782 nM 10.11
CHEMBL3665167 — IC50 = 0.0797 nM 10.10
CHEMBL3335688 — IC50 = 0.0822 nM 10.09
CHEMBL3665215 — IC50 = 0.0838 nM 10.08
CHEMBL3665137 — IC50 = 0.0847 nM 10.07
CHEMBL3335691 — IC50 = 0.088 nM 10.06
CHEMBL3665145 — IC50 = 0.0876 nM 10.06
CHEMBL3665175 — IC50 = 0.09 nM 10.05