Assay Detail
Binding
CHEMBL3707887
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Inhibition Assay: In vitro inhibition assay using various enzyme.
15
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Compound useful for the treatment of degenerative and inflammatory diseases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.54 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360356 | — | — | 1 | 7.81 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 4 | 7.50 |
| CHEMBL3360353 | — | — | 3 | 7.41 |
| CHEMBL3651604 | — | — | 1 | 7.18 |
| CHEMBL3651603 | — | — | 1 | 6.07 |
| CHEMBL3651602 | — | — | 2 | 5.87 |
| CHEMBL3648428 | — | — | 1 | 5.75 |
| CHEMBL3360354 | — | — | 1 | 5.29 |
| CHEMBL3651601 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360356 | — | IC50 | = | 15.51 | nM | 7.81 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 31.37 | nM | 7.50 |
| CHEMBL3360353 | — | IC50 | = | 38.73 | nM | 7.41 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 41.16 | nM | 7.39 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 55.49 | nM | 7.26 |
| CHEMBL3651604 | — | IC50 | = | 65.42 | nM | 7.18 |
| CHEMBL3360353 | — | IC50 | = | 152.3 | nM | 6.82 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 167.34 | nM | 6.78 |
| CHEMBL3360353 | — | IC50 | = | 184.7 | nM | 6.73 |
| CHEMBL3651603 | — | IC50 | = | 848.7 | nM | 6.07 |
| CHEMBL3651602 | — | IC50 | = | 1355.0 | nM | 5.87 |
| CHEMBL3648428 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL3360354 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL3651601 | — | IC50 | = | 6449.0 | nM | 5.19 |
| CHEMBL3651602 | — | IC50 | = | 7731.0 | nM | 5.11 |