Assay Detail
Functional
CHEMBL3720768
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Agonist activity at RXFP1 receptor in human THP1 cells assessed as stimulation of cAMP production incubated for 30 mins by HTRF assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulators of the relaxin receptor 1
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.63 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3715235 | — | — | 1 | 6.98 |
| CHEMBL3718400 | — | — | 1 | 6.97 |
| CHEMBL3715081 | — | — | 1 | 6.91 |
| CHEMBL3716980 | — | — | 1 | 6.70 |
| CHEMBL3717211 | — | — | 1 | 6.45 |
| CHEMBL3717389 | — | — | 1 | 6.44 |
| CHEMBL3717089 | — | — | 1 | 6.33 |
| CHEMBL3717103 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3715235 | — | EC50 | = | 105.1 | nM | 6.98 |
| CHEMBL3718400 | — | EC50 | = | 107.3 | nM | 6.97 |
| CHEMBL3715081 | — | EC50 | = | 123.7 | nM | 6.91 |
| CHEMBL3716980 | — | EC50 | = | 199.9 | nM | 6.70 |
| CHEMBL3717211 | — | EC50 | = | 358.5 | nM | 6.45 |
| CHEMBL3717389 | — | EC50 | = | 362.2 | nM | 6.44 |
| CHEMBL3717089 | — | EC50 | = | 471.1 | nM | 6.33 |
| CHEMBL3717103 | — | EC50 | = | 523.1 | nM | 6.28 |