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Assay Detail

CHEMBL3720907

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Functional
Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as calcium mobilization by fluo-4-AM dye based FLIPR assay
ChEMBL ↗
140
Total Activities
140
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HEK-293T
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

T1R1/T1R3 (CHEMBL3832641) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
(2008)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 140 6.15 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3717666 — — 1 6.92
CHEMBL3719142 — — 1 6.92
CHEMBL3716217 — — 1 6.85
CHEMBL3717202 — — 1 6.75
CHEMBL3715156 — — 1 6.75
CHEMBL3718834 — — 1 6.72
CHEMBL3718431 — — 1 6.70
CHEMBL3719352 — — 1 6.70
CHEMBL3719220 — — 1 6.70
CHEMBL3718284 — — 1 6.66
CHEMBL3714931 — — 1 6.66
CHEMBL3718656 — — 1 6.60
CHEMBL3715023 — — 1 6.60
CHEMBL3715281 — — 1 6.58
CHEMBL3717504 — — 1 6.54
CHEMBL3716393 — — 1 6.54
CHEMBL3717894 — — 1 6.54
CHEMBL3717168 — — 1 6.54
CHEMBL3715808 — — 1 6.51
CHEMBL3718018 — — 1 6.50
CHEMBL3717726 — — 1 6.50
CHEMBL3715084 — — 1 6.50
CHEMBL3716141 — — 1 6.50
CHEMBL3716606 — — 1 6.48
CHEMBL3717635 — — 1 6.47
CHEMBL3719291 — — 1 6.47
CHEMBL3718505 — — 1 6.47
CHEMBL3717722 — — 1 6.46
CHEMBL3718486 — — 1 6.46
CHEMBL3715936 — — 1 6.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3717666 — EC50 = 120.0 nM 6.92
CHEMBL3719142 — EC50 = 120.0 nM 6.92
CHEMBL3716217 — EC50 = 140.0 nM 6.85
CHEMBL3715156 — EC50 = 180.0 nM 6.75
CHEMBL3717202 — EC50 = 180.0 nM 6.75
CHEMBL3718834 — EC50 = 190.0 nM 6.72
CHEMBL3718431 — EC50 = 200.0 nM 6.70
CHEMBL3719352 — EC50 = 200.0 nM 6.70
CHEMBL3719220 — EC50 = 200.0 nM 6.70
CHEMBL3714931 — EC50 = 220.0 nM 6.66
CHEMBL3718284 — EC50 = 220.0 nM 6.66
CHEMBL3718656 — EC50 = 250.0 nM 6.60
CHEMBL3715023 — EC50 = 250.0 nM 6.60
CHEMBL3715281 — EC50 = 260.0 nM 6.58
CHEMBL3716393 — EC50 = 290.0 nM 6.54
CHEMBL3717168 — EC50 = 290.0 nM 6.54
CHEMBL3717504 — EC50 = 290.0 nM 6.54
CHEMBL3717894 — EC50 = 290.0 nM 6.54
CHEMBL3715808 — EC50 = 310.0 nM 6.51
CHEMBL3715084 — EC50 = 320.0 nM 6.50
CHEMBL3717726 — EC50 = 320.0 nM 6.50
CHEMBL3716141 — EC50 = 320.0 nM 6.50
CHEMBL3718018 — EC50 = 320.0 nM 6.50
CHEMBL3716606 — EC50 = 330.0 nM 6.48
CHEMBL3717635 — EC50 = 340.0 nM 6.47
CHEMBL3719291 — EC50 = 340.0 nM 6.47
CHEMBL3718505 — EC50 = 340.0 nM 6.47
CHEMBL3718486 — EC50 = 350.0 nM 6.46
CHEMBL3717722 — EC50 = 350.0 nM 6.46
CHEMBL3715936 — EC50 = 370.0 nM 6.43
CHEMBL3715875 — EC50 = 370.0 nM 6.43
CHEMBL3717692 — EC50 = 380.0 nM 6.42
CHEMBL3715364 — EC50 = 390.0 nM 6.41
CHEMBL3717599 — EC50 = 400.0 nM 6.40
CHEMBL3715954 — EC50 = 400.0 nM 6.40
CHEMBL3716867 — EC50 = 440.0 nM 6.36
CHEMBL3716609 — EC50 = 460.0 nM 6.34
CHEMBL3719237 — EC50 = 460.0 nM 6.34
CHEMBL3714998 — EC50 = 460.0 nM 6.34
CHEMBL3715895 — EC50 = 470.0 nM 6.33
CHEMBL3717517 — EC50 = 490.0 nM 6.31
CHEMBL3716463 — EC50 = 490.0 nM 6.31
CHEMBL3717760 — EC50 = 490.0 nM 6.31
CHEMBL3717013 — EC50 = 500.0 nM 6.30
CHEMBL3718106 — EC50 = 500.0 nM 6.30
CHEMBL3718519 — EC50 = 510.0 nM 6.29
CHEMBL3717246 — EC50 = 530.0 nM 6.28
CHEMBL3716092 — EC50 = 520.0 nM 6.28
CHEMBL3718215 — EC50 = 530.0 nM 6.28
CHEMBL3719174 — EC50 = 520.0 nM 6.28