Assay Detail
Binding
CHEMBL3720934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged full-length human PBK (1 to 322 residues) using FITC-labeled histone-H3 peptide substrate incubated for 1 hr by fluorescence polarization based assay
75
Total Activities
74
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lymphokine-activated killer T-cell-originated protein kinase (CHEMBL4896) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazopyridine derivatives and pbk inhibitors containing the same
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 75 | 6.10 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3716544 | — | — | 1 | 8.28 |
| CHEMBL3715360 | — | — | 1 | 8.28 |
| CHEMBL3715388 | — | — | 1 | 7.62 |
| CHEMBL3716635 | — | — | 1 | 7.48 |
| CHEMBL3718105 | — | — | 1 | 7.47 |
| CHEMBL3715121 | — | — | 1 | 7.47 |
| CHEMBL3718439 | — | — | 1 | 7.46 |
| CHEMBL3715494 | — | — | 1 | 7.44 |
| CHEMBL3718039 | — | — | 1 | 7.41 |
| CHEMBL3718730 | — | — | 1 | 7.26 |
| CHEMBL3717059 | — | — | 1 | 7.23 |
| CHEMBL3717532 | — | — | 1 | 7.20 |
| CHEMBL3718268 | — | — | 1 | 7.20 |
| CHEMBL3715032 | — | — | 1 | 7.14 |
| CHEMBL3715508 | — | — | 1 | 7.13 |
| CHEMBL3717297 | — | — | 1 | 7.11 |
| CHEMBL3718758 | — | — | 1 | 7.01 |
| CHEMBL3715825 | — | — | 1 | 7.00 |
| CHEMBL3719067 | — | — | 1 | 6.96 |
| CHEMBL3717063 | — | — | 1 | 6.85 |
| CHEMBL3718368 | — | — | 1 | 6.82 |
| CHEMBL3716639 | — | — | 1 | 6.80 |
| CHEMBL3717470 | — | — | 2 | 6.75 |
| CHEMBL3718956 | — | — | 1 | 6.66 |
| CHEMBL3717200 | — | — | 1 | 6.54 |
| CHEMBL3715412 | — | — | 1 | 6.52 |
| CHEMBL3717174 | — | — | 1 | 6.48 |
| CHEMBL3718783 | — | — | 1 | 6.47 |
| CHEMBL3715259 | — | — | 1 | 6.47 |
| CHEMBL3718661 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3716544 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3715360 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL3715388 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3716635 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3718105 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3715121 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3718439 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3715494 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3718039 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3718730 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3717059 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3718268 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3717532 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3715032 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3715508 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3717297 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3718758 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3715825 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3719067 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3717063 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3718368 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3716639 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3717470 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3718956 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3717200 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3715412 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3717174 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3718783 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3715259 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3718661 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3718423 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3718636 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3716143 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3718407 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3718575 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3717030 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3715533 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3716309 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3716727 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3717470 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3716044 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717765 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3714773 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3719168 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3714893 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3716598 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3719325 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3716396 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3716516 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3715553 | — | IC50 | = | 2500.0 | nM | 5.60 |