Assay Detail
Binding
CHEMBL3721076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant full-length GST-tagged human GRK6 using peptide substrate peptide-216 incubated for 7 hrs
158
Total Activities
158
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibiting G-protein coupled receptor 6 kinase polypeptides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 158 | 5.11 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3718518 | — | — | 1 | 6.38 |
| CHEMBL3718739 | — | — | 1 | 6.37 |
| CHEMBL3718989 | — | — | 1 | 6.29 |
| CHEMBL3716736 | — | — | 1 | 6.12 |
| CHEMBL3717012 | — | — | 1 | 6.12 |
| CHEMBL3716413 | — | — | 1 | 6.04 |
| CHEMBL3717241 | — | — | 1 | 6.01 |
| CHEMBL3718188 | — | — | 1 | 5.99 |
| CHEMBL3715230 | — | — | 1 | 5.98 |
| CHEMBL3715846 | — | — | 1 | 5.98 |
| CHEMBL3716478 | — | — | 1 | 5.86 |
| CHEMBL3719304 | — | — | 1 | 5.85 |
| CHEMBL3716051 | — | — | 1 | 5.84 |
| CHEMBL607421 | — | — | 1 | 5.84 |
| CHEMBL590178 | — | — | 1 | 5.81 |
| CHEMBL3717328 | — | — | 1 | 5.64 |
| CHEMBL3719088 | — | — | 1 | 5.59 |
| CHEMBL3718480 | — | — | 1 | 5.58 |
| CHEMBL3716418 | — | — | 1 | 5.57 |
| CHEMBL3718269 | — | — | 1 | 5.55 |
| CHEMBL3717135 | — | — | 1 | 5.52 |
| CHEMBL3715663 | — | — | 1 | 5.48 |
| CHEMBL3715789 | — | — | 1 | 5.47 |
| CHEMBL3715401 | — | — | 1 | 5.47 |
| CHEMBL3715130 | — | — | 1 | 5.45 |
| CHEMBL3717649 | — | — | 1 | 5.39 |
| CHEMBL3716389 | — | — | 1 | 5.36 |
| CHEMBL3714961 | — | — | 1 | 5.35 |
| CHEMBL3716349 | — | — | 1 | 5.35 |
| CHEMBL3717496 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3718518 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL3718739 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL3718989 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3717012 | — | IC50 | = | 757.0 | nM | 6.12 |
| CHEMBL3716736 | — | IC50 | = | 751.0 | nM | 6.12 |
| CHEMBL3716413 | — | IC50 | = | 919.0 | nM | 6.04 |
| CHEMBL3717241 | — | IC50 | = | 973.0 | nM | 6.01 |
| CHEMBL3718188 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3715846 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3715230 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3716478 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL3719304 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3716051 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL607421 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL590178 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL3717328 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL3719088 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL3718480 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL3716418 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL3718269 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL3717135 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL3715663 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3715789 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL3715401 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3715130 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL3717649 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL3716389 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL3714961 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL3716349 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL3717118 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL3717496 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL2159845 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3716868 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3716337 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL3717096 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL3717039 | — | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL1571373 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL3716367 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3716535 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL3716466 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL3715220 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3716327 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL1402572 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL3715181 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL3718128 | — | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL3716984 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL55415 | SCUTELLAREIN | IC50 | = | 6610.0 | nM | 5.18 |
| CHEMBL3715521 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL3718376 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3717003 | — | IC50 | = | 6880.0 | nM | 5.16 |