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Assay Detail

CHEMBL3721115

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to pyruvate dehydrogenase kinase (unknown origin) by VER-00160364 probe based fluorescence polarization assay
ChEMBL ↗
269
Total Activities
269
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Pyruvate dehydrogenase kinase (CHEMBL2096665) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Tetrahydroisoquinoline compounds and their use as pyruvate dehydrogenase kinase inhibitors
(2015)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 269 6.77 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3718319 — — 1 8.00
CHEMBL3717827 — — 1 8.00
CHEMBL3716746 — — 1 8.00
CHEMBL3715771 — — 1 8.00
CHEMBL3715972 — — 1 8.00
CHEMBL3715049 — — 1 8.00
CHEMBL3717836 — — 1 8.00
CHEMBL3715757 — — 1 8.00
CHEMBL3715842 — — 1 8.00
CHEMBL3716740 — — 1 8.00
CHEMBL3715512 — — 1 8.00
CHEMBL3717025 — — 1 8.00
CHEMBL3715072 — — 1 8.00
CHEMBL3715330 — — 1 8.00
CHEMBL3717613 — — 1 8.00
CHEMBL3718383 — — 1 8.00
CHEMBL3717764 — — 1 8.00
CHEMBL3717459 — — 1 8.00
CHEMBL3717436 — — 1 8.00
CHEMBL3714928 — — 1 8.00
CHEMBL3715598 — — 1 8.00
CHEMBL3717052 — — 1 8.00
CHEMBL3719305 — — 1 8.00
CHEMBL3716404 — — 1 8.00
CHEMBL3715313 — — 1 8.00
CHEMBL3719004 — — 1 8.00
CHEMBL3716176 — — 1 8.00
CHEMBL3716924 — — 1 8.00
CHEMBL3717579 — — 1 8.00
CHEMBL3719344 — — 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3715072 — IC50 = 10.0 nM 8.00
CHEMBL3719348 — IC50 = 10.0 nM 8.00
CHEMBL3715964 — IC50 = 10.0 nM 8.00
CHEMBL3716404 — IC50 = 10.0 nM 8.00
CHEMBL3715313 — IC50 = 10.0 nM 8.00
CHEMBL3717025 — IC50 = 10.0 nM 8.00
CHEMBL3719035 — IC50 = 10.0 nM 8.00
CHEMBL3717436 — IC50 = 10.0 nM 8.00
CHEMBL3717052 — IC50 = 10.0 nM 8.00
CHEMBL3714928 — IC50 = 10.0 nM 8.00
CHEMBL3718319 — IC50 = 10.0 nM 8.00
CHEMBL3717579 — IC50 = 10.0 nM 8.00
CHEMBL3719333 — IC50 = 10.0 nM 8.00
CHEMBL3715044 — IC50 = 10.0 nM 8.00
CHEMBL3716924 — IC50 = 10.0 nM 8.00
CHEMBL3715330 — IC50 = 10.0 nM 8.00
CHEMBL3719004 — IC50 = 10.0 nM 8.00
CHEMBL3716176 — IC50 = 10.0 nM 8.00
CHEMBL3718383 — IC50 = 10.0 nM 8.00
CHEMBL3719351 — IC50 = 10.0 nM 8.00
CHEMBL3715598 — IC50 = 10.0 nM 8.00
CHEMBL3719344 — IC50 = 10.0 nM 8.00
CHEMBL3717613 — IC50 = 10.0 nM 8.00
CHEMBL3717764 — IC50 = 10.0 nM 8.00
CHEMBL3717459 — IC50 = 10.0 nM 8.00
CHEMBL3715512 — IC50 = 10.0 nM 8.00
CHEMBL3716740 — IC50 = 10.0 nM 8.00
CHEMBL3715842 — IC50 = 10.0 nM 8.00
CHEMBL3715757 — IC50 = 10.0 nM 8.00
CHEMBL3717836 — IC50 = 10.0 nM 8.00
CHEMBL3715972 — IC50 = 10.0 nM 8.00
CHEMBL3715771 — IC50 = 10.0 nM 8.00
CHEMBL3716746 — IC50 = 10.0 nM 8.00
CHEMBL3717827 — IC50 = 10.0 nM 8.00
CHEMBL3717940 — IC50 = 10.0 nM 8.00
CHEMBL3719305 — IC50 = 10.0 nM 8.00
CHEMBL3714889 — IC50 = 10.0 nM 8.00
CHEMBL3717799 — IC50 = 10.0 nM 8.00
CHEMBL3715049 — IC50 = 10.0 nM 8.00
CHEMBL3717668 — IC50 = 100.0 nM 7.00
CHEMBL3717913 — IC50 = 100.0 nM 7.00
CHEMBL3716735 — IC50 = 100.0 nM 7.00
CHEMBL3718102 — IC50 = 100.0 nM 7.00
CHEMBL3715624 — IC50 = 100.0 nM 7.00
CHEMBL3717626 — IC50 = 100.0 nM 7.00
CHEMBL3715859 — IC50 = 100.0 nM 7.00
CHEMBL3717712 — IC50 = 100.0 nM 7.00
CHEMBL3716145 — IC50 = 100.0 nM 7.00
CHEMBL3716109 — IC50 = 100.0 nM 7.00
CHEMBL3719313 — IC50 = 100.0 nM 7.00