Assay Detail
Binding
CHEMBL3721116
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Inhibition of pyruvate dehydrogenase kinase in human PC3 cells incubated for 90 mins by phospho(Ser293)E1alpha MSP ELISA method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Tetrahydroisoquinoline compounds and their use as pyruvate dehydrogenase kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.90 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3718102 | — | — | 1 | 6.00 |
| CHEMBL3718006 | — | — | 1 | 6.00 |
| CHEMBL3714831 | — | — | 1 | 6.00 |
| CHEMBL3719305 | — | — | 1 | 6.00 |
| CHEMBL3718698 | — | — | 1 | 6.00 |
| CHEMBL3716404 | — | — | 1 | 6.00 |
| CHEMBL3717579 | — | — | 1 | 6.00 |
| CHEMBL3717609 | — | — | 1 | 6.00 |
| CHEMBL3716746 | — | — | 1 | 6.00 |
| CHEMBL3717438 | — | — | 1 | 6.00 |
| CHEMBL3718330 | — | — | 1 | 6.00 |
| CHEMBL3716584 | — | — | 1 | 6.00 |
| CHEMBL3716827 | — | — | 1 | 6.00 |
| CHEMBL3717459 | — | — | 1 | 6.00 |
| CHEMBL3719124 | — | — | 1 | 6.00 |
| CHEMBL3717621 | — | — | 1 | 6.00 |
| CHEMBL3716663 | — | — | 1 | 6.00 |
| CHEMBL3714966 | — | — | 1 | 6.00 |
| CHEMBL3714793 | — | — | 1 | 6.00 |
| CHEMBL3715902 | — | — | 1 | 6.00 |
| CHEMBL3719250 | — | — | 1 | 6.00 |
| CHEMBL3717864 | — | — | 1 | 6.00 |
| CHEMBL3716377 | — | — | 1 | 6.00 |
| CHEMBL3718319 | — | — | 1 | 6.00 |
| CHEMBL3716145 | — | — | 1 | 6.00 |
| CHEMBL3717668 | — | — | 1 | 6.00 |
| CHEMBL3717052 | — | — | 1 | 6.00 |
| CHEMBL3717988 | — | — | 1 | 5.00 |
| CHEMBL3717764 | — | — | 1 | 5.00 |
| CHEMBL3718683 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3718102 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3718006 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3714831 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3719305 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3718698 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3716404 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717579 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717609 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3716746 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717438 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3718330 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3716584 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3716827 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717459 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3719124 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717621 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3716663 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3714966 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3714793 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3715902 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3719250 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717864 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3716377 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3718319 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3716145 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717668 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717052 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3717988 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3717764 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3718683 | — | IC50 | = | 10000.0 | nM | 5.00 |