Assay Detail
Binding
CHEMBL3721247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Mixed type inhibition of human PFKFB3 expressed in Escherichia coli BL21 (DE3) assessed as reduction in NADH consumption using fructose-6-phosphate incubated for 15 mins by spectrophotometry based pyruvate kinase and LDH enzyme coupled kinetic assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (CHEMBL2331053) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Family of PFKFB3 inhibitors with anti-neoplastic activities
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 4.60 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3105848 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3105848 | — | Ki | = | 25100.0 | nM | 4.60 |