Assay Detail
Functional
CHEMBL3734079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Orai1/STIM1 expressed in HEK293 cells assessed as intracellular calcium level after 30 mins by FLIPR assay
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Compounds that modulate intracellular calcium
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3729649 | — | — | 1 | 6.22 |
| CHEMBL3732488 | — | — | 1 | 6.22 |
| CHEMBL3727419 | — | — | 1 | 6.22 |
| CHEMBL3731241 | — | — | 1 | 6.22 |
| CHEMBL3731683 | — | — | 1 | 6.22 |
| CHEMBL3727719 | — | — | 1 | 6.22 |
| CHEMBL3729028 | — | — | 1 | 6.22 |
| CHEMBL3728586 | — | — | 1 | 6.22 |
| CHEMBL3732851 | — | — | 1 | 6.22 |
| CHEMBL3733110 | — | — | 1 | 6.22 |
| CHEMBL3727896 | — | — | 1 | 6.22 |
| CHEMBL3730437 | — | — | 1 | - |
| CHEMBL3732391 | — | — | 1 | - |
| CHEMBL3730422 | — | — | 1 | - |
| CHEMBL3728333 | — | — | 1 | - |
| CHEMBL3732413 | — | — | 1 | - |
| CHEMBL3730066 | — | — | 1 | - |
| CHEMBL3730763 | — | — | 1 | - |
| CHEMBL3732356 | — | — | 1 | - |
| CHEMBL3731668 | — | — | 1 | - |
| CHEMBL3731436 | — | — | 1 | - |
| CHEMBL3730725 | — | — | 1 | - |
| CHEMBL3728717 | — | — | 1 | - |
| CHEMBL3727713 | — | — | 1 | - |
| CHEMBL3730653 | — | — | 1 | - |
| CHEMBL3731071 | — | — | 1 | - |
| CHEMBL3732507 | — | — | 1 | - |
| CHEMBL3728982 | — | — | 1 | - |
| CHEMBL3727557 | — | — | 1 | - |
| CHEMBL3727650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3729649 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3732488 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3727419 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3731241 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3731683 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3727719 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3729028 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3728586 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3732851 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3733110 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3727896 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3732172 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3732550 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3733096 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3728688 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3732454 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3732872 | — | IC50 | - | — | - | |
| CHEMBL3731997 | — | IC50 | - | — | - | |
| CHEMBL3729608 | — | IC50 | - | — | - | |
| CHEMBL3729622 | — | IC50 | - | — | - | |
| CHEMBL3727596 | — | IC50 | - | — | - | |
| CHEMBL3728373 | — | IC50 | - | — | - | |
| CHEMBL3730994 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3727582 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3733011 | — | IC50 | - | — | - | |
| CHEMBL3730095 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3731956 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3733351 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3727392 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3729327 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3731436 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3727650 | — | IC50 | - | — | - | |
| CHEMBL3727557 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3728982 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3732507 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3731071 | — | IC50 | - | — | - | |
| CHEMBL3730653 | — | IC50 | - | — | - | |
| CHEMBL3727713 | — | IC50 | - | — | - | |
| CHEMBL3728717 | — | IC50 | - | — | - | |
| CHEMBL3730725 | — | IC50 | - | — | - | |
| CHEMBL3732517 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3731668 | — | IC50 | > | 600.0 | nM | - |
| CHEMBL3732356 | — | IC50 | - | — | - | |
| CHEMBL3730763 | — | IC50 | - | — | - | |
| CHEMBL3730066 | — | IC50 | - | — | - | |
| CHEMBL3732413 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3728333 | — | IC50 | - | — | - | |
| CHEMBL3730422 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3732391 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3730437 | — | IC50 | > | 1200.0 | nM | - |