Assay Detail
Binding
CHEMBL3734545
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Inhibition of recombinant human STIM1/Orai1 expressed in HEK293 cells assessed as inhibition of peak basal signal after 30 mins by fluo4-AM dye-based FLIPR assay
78
Total Activities
78
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Compounds that modulate intracellular calcium
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 76 | 6.22 | 6.22 |
| Efficacy | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3732761 | — | — | 1 | 6.22 |
| CHEMBL3728969 | — | — | 1 | 6.22 |
| CHEMBL3732982 | — | — | 1 | 6.22 |
| CHEMBL3732114 | — | — | 1 | 6.22 |
| CHEMBL3727447 | — | — | 1 | 6.22 |
| CHEMBL3731485 | — | — | 1 | 6.22 |
| CHEMBL3728232 | — | — | 1 | 6.22 |
| CHEMBL3729551 | — | — | 1 | 6.22 |
| CHEMBL3728468 | — | — | 1 | 6.22 |
| CHEMBL3727611 | — | — | 1 | 6.22 |
| CHEMBL3731488 | — | — | 1 | 6.22 |
| CHEMBL3730656 | — | — | 1 | 6.22 |
| CHEMBL3728323 | — | — | 1 | 6.22 |
| CHEMBL3731765 | — | — | 1 | 6.22 |
| CHEMBL3731250 | — | — | 1 | 6.22 |
| CHEMBL3727989 | — | — | 1 | 6.22 |
| CHEMBL3732779 | — | — | 1 | - |
| CHEMBL3733237 | — | — | 1 | - |
| CHEMBL3730176 | — | — | 1 | - |
| CHEMBL3728931 | — | — | 1 | - |
| CHEMBL3728450 | — | — | 1 | - |
| CHEMBL3733040 | — | — | 1 | - |
| CHEMBL3729234 | — | — | 1 | - |
| CHEMBL3728713 | — | — | 1 | - |
| CHEMBL3730009 | — | — | 1 | - |
| CHEMBL3732677 | — | — | 1 | - |
| CHEMBL3730254 | — | — | 1 | - |
| CHEMBL3727734 | — | — | 1 | - |
| CHEMBL3729158 | — | — | 1 | - |
| CHEMBL3732999 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3732761 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3731250 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3728969 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3732982 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3732114 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3727447 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3731485 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3728232 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3729551 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3728468 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3727611 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3731488 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3730656 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3728323 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3731765 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3727989 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3731651 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3729109 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3729900 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3727938 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3728875 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3729841 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3729101 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3730740 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3728704 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3729771 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3730598 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3729739 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3730339 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3728485 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3731030 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3729283 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3728825 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3733040 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3732999 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3729158 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3727734 | — | Efficacy | < | 50.0 | % | - |
| CHEMBL3730254 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3732677 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3730009 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3728713 | — | IC50 | - | — | - | |
| CHEMBL3729234 | — | IC50 | - | — | - | |
| CHEMBL3733355 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3728450 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3728931 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3730176 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3733237 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3732779 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL3732620 | — | IC50 | < | 600.0 | nM | - |
| CHEMBL3728218 | — | IC50 | > | 1200.0 | nM | - |