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Assay Detail

CHEMBL3734546

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of STIM1/Orai1 in rat RBL2H3 cells assessed as inhibition of upslope incubated for 5 mins followed by thapsigargin addition for 25 mins measured for 7 secs by fluo4-AM dye-based FLIPR assay
84
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type RBL-2H3
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

ORAI1/STIM1 (CHEMBL3832645)
Type PROTEIN COMPLEX
Organism Rattus norvegicus

Publication

Compounds that modulate intracellular calcium
(2012)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 84 6.22 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3732761 1 6.22
CHEMBL3728969 1 6.22
CHEMBL3729739 1 6.22
CHEMBL3732450 1 6.22
CHEMBL3727649 1 6.22
CHEMBL3731310 1 6.22
CHEMBL3731030 1 6.22
CHEMBL3733059 1 6.22
CHEMBL3731485 1 6.22
CHEMBL3727447 1 6.22
CHEMBL3733237 1 6.22
CHEMBL3727600 1 6.22
CHEMBL3731964 1 6.22
CHEMBL3728704 1 -
CHEMBL3729771 1 -
CHEMBL3731651 1 -
CHEMBL3729158 1 -
CHEMBL3730254 1 -
CHEMBL3732677 1 -
CHEMBL3728713 1 -
CHEMBL3729234 1 -
CHEMBL3728323 1 -
CHEMBL3728931 1 -
CHEMBL3733040 1 -
CHEMBL3730009 1 -
CHEMBL3732779 1 -
CHEMBL3727734 1 -
CHEMBL3732110 1 -
CHEMBL3731765 1 -
CHEMBL3730176 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3732761 IC50 = 600.0 nM 6.22
CHEMBL3728969 IC50 = 600.0 nM 6.22
CHEMBL3729739 IC50 = 600.0 nM 6.22
CHEMBL3732450 IC50 = 600.0 nM 6.22
CHEMBL3727649 IC50 = 600.0 nM 6.22
CHEMBL3731310 IC50 = 600.0 nM 6.22
CHEMBL3731030 IC50 = 600.0 nM 6.22
CHEMBL3733059 IC50 = 600.0 nM 6.22
CHEMBL3731485 IC50 = 600.0 nM 6.22
CHEMBL3727447 IC50 = 600.0 nM 6.22
CHEMBL3733237 IC50 = 600.0 nM 6.22
CHEMBL3727600 IC50 = 600.0 nM 6.22
CHEMBL3731964 IC50 = 600.0 nM 6.22
CHEMBL3729841 IC50 < 600.0 nM -
CHEMBL3727872 IC50 - -
CHEMBL3728875 IC50 < 600.0 nM -
CHEMBL3727938 IC50 < 600.0 nM -
CHEMBL3732114 IC50 < 600.0 nM -
CHEMBL3729900 IC50 < 600.0 nM -
CHEMBL3729109 IC50 < 600.0 nM -
CHEMBL3730610 IC50 - -
CHEMBL3729551 IC50 < 600.0 nM -
CHEMBL3733355 IC50 < 600.0 nM -
CHEMBL3727989 IC50 < 600.0 nM -
CHEMBL3728468 IC50 - -
CHEMBL3727611 IC50 - -
CHEMBL3731488 IC50 < 600.0 nM -
CHEMBL3728218 IC50 - -
CHEMBL3732620 IC50 < 600.0 nM -
CHEMBL3728855 IC50 < 600.0 nM -
CHEMBL3732547 IC50 < 600.0 nM -
CHEMBL3729234 IC50 - -
CHEMBL3730176 IC50 - -
CHEMBL3731765 IC50 < 600.0 nM -
CHEMBL3732110 IC50 - -
CHEMBL3727734 IC50 < 600.0 nM -
CHEMBL3732779 IC50 < 600.0 nM -
CHEMBL3730009 IC50 < 600.0 nM -
CHEMBL3733040 IC50 < 600.0 nM -
CHEMBL3728931 IC50 > 1200.0 nM -
CHEMBL3728323 IC50 < 600.0 nM -
CHEMBL3729101 IC50 < 600.0 nM -
CHEMBL3728713 IC50 - -
CHEMBL3732677 IC50 < 600.0 nM -
CHEMBL3730254 IC50 < 600.0 nM -
CHEMBL3729158 IC50 < 600.0 nM -
CHEMBL3731651 IC50 < 600.0 nM -
CHEMBL3729771 IC50 < 600.0 nM -
CHEMBL3728704 IC50 < 600.0 nM -
CHEMBL3730740 IC50 < 600.0 nM -