Assay Detail
Functional
CHEMBL3734553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant FPRL2 receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
422
Total Activities
413
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 422 | 6.14 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3728341 | — | — | 1 | 8.42 |
| CHEMBL3733191 | — | — | 1 | 8.18 |
| CHEMBL3730664 | — | — | 1 | 8.13 |
| CHEMBL3731635 | — | — | 1 | 7.92 |
| CHEMBL3730156 | — | — | 1 | 7.89 |
| CHEMBL3731671 | — | — | 1 | 7.82 |
| CHEMBL3731035 | — | — | 1 | 7.82 |
| CHEMBL3728830 | — | — | 1 | 7.82 |
| CHEMBL3728649 | — | — | 1 | 7.80 |
| CHEMBL3731316 | — | — | 1 | 7.80 |
| CHEMBL3730919 | — | — | 1 | 7.75 |
| CHEMBL3731064 | — | — | 1 | 7.70 |
| CHEMBL3733261 | — | — | 1 | 7.58 |
| CHEMBL3732345 | — | — | 1 | 7.57 |
| CHEMBL3731822 | — | — | 1 | 7.57 |
| CHEMBL3732539 | — | — | 1 | 7.55 |
| CHEMBL3729493 | — | — | 1 | 7.54 |
| CHEMBL3728150 | — | — | 1 | 7.52 |
| CHEMBL3729722 | — | — | 2 | 7.50 |
| CHEMBL3732902 | — | — | 1 | 7.48 |
| CHEMBL3729460 | — | — | 1 | 7.39 |
| CHEMBL3729342 | — | — | 1 | 7.36 |
| CHEMBL3728769 | — | — | 1 | 7.34 |
| CHEMBL3728352 | — | — | 1 | 7.33 |
| CHEMBL3732978 | — | — | 1 | 7.28 |
| CHEMBL3727697 | — | — | 1 | 7.24 |
| CHEMBL3730217 | — | — | 1 | 7.24 |
| CHEMBL3730955 | — | — | 1 | 7.22 |
| CHEMBL3729805 | — | — | 1 | 7.21 |
| CHEMBL3730330 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3728341 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3733191 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3730664 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3731635 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3730156 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3731035 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3731671 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3728830 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3728649 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3731316 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3730919 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3731064 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3733261 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3731822 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3732345 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3732539 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3729493 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3728150 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3729722 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3732902 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3729460 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3729342 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3728769 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3728352 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3732978 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3730217 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3727697 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3730955 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3730330 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3729805 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3731680 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3728125 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3729273 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3731599 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3728646 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3728119 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3732566 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3728781 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3730257 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3733287 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3732885 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3733253 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3732281 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3727450 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3732163 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3729633 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3730159 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3730922 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3728511 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3729899 | — | EC50 | = | 103.0 | nM | 6.99 |