Assay Detail
Binding
CHEMBL3736606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Sar1Ile8-Ang2 from human AT1 receptor expressed in CHO-K1 cell membranes after 180 mins
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel, potent and low-toxicity angiotensin II receptor type 1 (AT1) blockers: Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazoles with a chiral center.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.03 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3735744 | — | — | 1 | 8.96 |
| CHEMBL3736514 | — | — | 1 | 8.85 |
| CHEMBL3736244 | — | — | 1 | 8.57 |
| CHEMBL3735290 | — | — | 1 | 8.46 |
| CHEMBL3735409 | — | — | 1 | 8.30 |
| CHEMBL3734891 | — | — | 1 | 8.20 |
| CHEMBL3736440 | — | — | 1 | 8.14 |
| CHEMBL2058860 | — | — | 1 | 7.78 |
| CHEMBL3736295 | — | — | 1 | 7.71 |
| CHEMBL3735588 | — | — | 1 | 7.64 |
| CHEMBL2435818 | — | — | 1 | 7.64 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.54 |
| CHEMBL3735769 | — | — | 1 | 7.41 |
| CHEMBL3735652 | — | — | 1 | 7.39 |
| CHEMBL3736451 | — | — | 1 | 7.24 |
| CHEMBL3736319 | — | — | 1 | 7.24 |
| CHEMBL3735804 | — | — | 1 | 7.21 |
| CHEMBL3735098 | — | — | 1 | 7.16 |
| CHEMBL3734763 | — | — | 1 | 7.06 |
| CHEMBL3736257 | — | — | 1 | 7.04 |
| CHEMBL3734819 | — | — | 1 | 7.03 |
| CHEMBL3735333 | — | — | 1 | 6.98 |
| CHEMBL3735487 | — | — | 1 | 6.97 |
| CHEMBL3734949 | — | — | 1 | 6.89 |
| CHEMBL3735446 | — | — | 1 | 6.80 |
| CHEMBL3735641 | — | — | 1 | 6.79 |
| CHEMBL3735492 | — | — | 1 | 6.67 |
| CHEMBL3735839 | — | — | 1 | 6.53 |
| CHEMBL3734989 | — | — | 1 | 6.46 |
| CHEMBL3736166 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3735744 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3736514 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3736244 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3735290 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3735409 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3734891 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3736440 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL2058860 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL3736295 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL3735588 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2435818 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL191 | LOSARTAN | IC50 | = | 28.6 | nM | 7.54 |
| CHEMBL3735769 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL3735652 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL3736319 | — | IC50 | = | 57.9 | nM | 7.24 |
| CHEMBL3736451 | — | IC50 | = | 57.4 | nM | 7.24 |
| CHEMBL3735804 | — | IC50 | = | 61.2 | nM | 7.21 |
| CHEMBL3735098 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3734763 | — | IC50 | = | 87.2 | nM | 7.06 |
| CHEMBL3736257 | — | IC50 | = | 90.5 | nM | 7.04 |
| CHEMBL3734819 | — | IC50 | = | 93.9 | nM | 7.03 |
| CHEMBL3735333 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3735487 | — | IC50 | = | 106.5 | nM | 6.97 |
| CHEMBL3734949 | — | IC50 | = | 128.6 | nM | 6.89 |
| CHEMBL3735446 | — | IC50 | = | 156.8 | nM | 6.80 |
| CHEMBL3735641 | — | IC50 | = | 161.1 | nM | 6.79 |
| CHEMBL3735492 | — | IC50 | = | 214.4 | nM | 6.67 |
| CHEMBL3735839 | — | IC50 | = | 293.1 | nM | 6.53 |
| CHEMBL3734989 | — | IC50 | = | 342.8 | nM | 6.46 |
| CHEMBL3736166 | — | IC50 | = | 366.3 | nM | 6.44 |
| CHEMBL3736202 | — | IC50 | = | 486.8 | nM | 6.31 |
| CHEMBL3735558 | — | IC50 | = | 503.3 | nM | 6.30 |
| CHEMBL3736336 | — | IC50 | = | 495.8 | nM | 6.30 |
| CHEMBL3735227 | — | IC50 | = | 621.6 | nM | 6.21 |
| CHEMBL3735653 | — | IC50 | = | 609.2 | nM | 6.21 |
| CHEMBL3735940 | — | IC50 | = | 671.4 | nM | 6.17 |
| CHEMBL3736346 | — | IC50 | = | 699.3 | nM | 6.16 |
| CHEMBL3735831 | — | IC50 | = | 738.4 | nM | 6.13 |
| CHEMBL3735390 | — | IC50 | = | 788.4 | nM | 6.10 |
| CHEMBL3734859 | — | IC50 | = | 1117.3 | nM | 5.95 |
| CHEMBL3736338 | — | IC50 | = | 1368.1 | nM | 5.86 |
| CHEMBL3734815 | — | IC50 | = | 1536.6 | nM | 5.81 |
| CHEMBL3735910 | — | IC50 | = | 1534.5 | nM | 5.81 |