Assay Detail
Binding
CHEMBL3736962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive binding affinity to Mcl-1 (unknown origin) using 5-FAM-Bid-BH3 peptide preincubated for 30 mins before 5-FAM-Bid-BH3 peptide addition and measured 20 mins after 5-FAM-Bid-BH3 peptide addition by fluorescence polarization assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.86 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.41 |
| CHEMBL3735206 | — | — | 1 | 6.28 |
| CHEMBL3735093 | — | — | 1 | 6.25 |
| CHEMBL3736460 | — | — | 1 | 6.24 |
| CHEMBL3736193 | — | — | 1 | 6.20 |
| CHEMBL3735919 | — | — | 1 | 6.13 |
| CHEMBL3735052 | — | — | 1 | 6.03 |
| CHEMBL3735669 | — | — | 1 | 6.00 |
| CHEMBL3736279 | — | — | 1 | 5.92 |
| CHEMBL3735545 | — | — | 1 | 5.92 |
| CHEMBL3735578 | — | — | 1 | 5.80 |
| CHEMBL3734919 | — | — | 1 | 5.72 |
| CHEMBL3736136 | — | — | 1 | 5.66 |
| CHEMBL3736270 | — | — | 1 | 5.66 |
| CHEMBL3735717 | — | — | 1 | 5.50 |
| CHEMBL3736039 | — | — | 1 | 5.48 |
| CHEMBL3735067 | — | — | 1 | 5.19 |
| CHEMBL3736139 | — | — | 1 | 5.08 |
| CHEMBL3735477 | — | — | 1 | - |
| CHEMBL3736200 | — | — | 1 | - |
| CHEMBL3734781 | — | — | 1 | - |
| CHEMBL3735269 | — | — | 1 | - |
| CHEMBL3735810 | — | — | 1 | - |
| CHEMBL3736148 | — | — | 1 | - |
| CHEMBL3735834 | — | — | 1 | - |
| CHEMBL3736152 | — | — | 1 | - |
| CHEMBL3735219 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51483 | GOSSYPOL | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL3735206 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL3735093 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL3736460 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL3736193 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL3735919 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL3735052 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL3735669 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL3736279 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3735545 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3735578 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3734919 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL3736136 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3736270 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3735717 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL3736039 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL3735067 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL3736139 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL3735477 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3736200 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3734781 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3735269 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3735810 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3736148 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3735834 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3736152 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3735219 | — | Ki | > | 10000.0 | nM | - |